The role of intracellular amyloid beta in alzheimer's disease
文献类型：期刊论文
| 作者 | Li, Meng; Chen, Liying; Lee, Daniel Hong Seng; Yu, Long-Chuan; Zhang, Yan |
| 刊名 | Progress in neurobiology
 |
| 出版日期 | 2007-10-01 |
| 卷号 | 83期号:3页码:131-139 |
| 关键词 | Alzheimer's disease Amyloid p peptide Neurotoxicity Neuronal loss |
| ISSN号 | 0301-0082 |
| DOI | 10.1016/j.pneurobio.2007.08.002 |
| 通讯作者 | Yu, long-chuan(yulc@pku.edu.cn) |
| 英文摘要 | Extracellular amyloid beta (a beta) that confers neurotoxicity and modulates synaptic plasticity and memory function has been central to the amyloid hypothesis of alzheimer's disease (ad) pathology. like many other misfolded proteins identified in neurodegenerative disorders, a beta also accumulates inside the ad neurons. this intracellular a beta affects a variety of cellular physiology from protein degradation, axonal transport, autophagy to apoptosis, further documenting the role of a beta in ad. therapeutics targeting intracellular a beta could be effective treatment for ad. (c) 2007 elsevier ltd. all rights reserved. |
| WOS关键词 | INTRANEURONAL-A-BETA ; INCLUSION-BODY MYOSITIS ; ELECTRON-MICROSCOPIC LOCALIZATION ; TRANSGENIC MOUSE MODEL ; APOPTOTIC CELL-DEATH ; PRECURSOR PROTEIN ; ENDOPLASMIC-RETICULUM ; PLAQUE-FORMATION ; HUMAN NEURONS ; DOWN-SYNDROME |
| WOS研究方向 | Neurosciences & Neurology |
| WOS类目 | Neurosciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000250978100001 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2380295 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Yu, Long-Chuan |
| 作者单位 | 1.Peking Univ, Coll Life Sci, Lab Neurobiol, State Key Lab Biomembrane & Membrane Biotechnol, Beijing 100871, Peoples R China 2.Biogen Inc, Cambridge, MA 02142 USA |
| 推荐引用方式 GB/T 7714 | Li, Meng,Chen, Liying,Lee, Daniel Hong Seng,et al. The role of intracellular amyloid beta in alzheimer's disease[J]. Progress in neurobiology,2007,83(3):131-139. |
| APA | Li, Meng,Chen, Liying,Lee, Daniel Hong Seng,Yu, Long-Chuan,&Zhang, Yan.(2007).The role of intracellular amyloid beta in alzheimer's disease.Progress in neurobiology,83(3),131-139. |
| MLA | Li, Meng,et al."The role of intracellular amyloid beta in alzheimer's disease".Progress in neurobiology 83.3(2007):131-139. |
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来源：中国科学院大学
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