Mutations in the type ii protein arginine methyltransferase atprmt5 result in pleiotropic developmental defects in arabidopsis(1[c][oa])
文献类型：期刊论文
| 作者 | Pei, Yanxi; Niu, Lifang; Lu, Falong; Liu, Chunyan; Zhai, Jixian; Kong, Xiangfeng; Cao, Xiaofeng |
| 刊名 | Plant physiology
 |
| 出版日期 | 2007-08-01 |
| 卷号 | 144期号:4页码:1913-1923 |
| ISSN号 | 0032-0889 |
| 通讯作者 | Cao, xiaofeng(xfcao@genetics.ac.cn) |
| 英文摘要 | Human protein arginine methyltransferase5 (prmt5) encodes a type ii protein arginine (arg) methyltransferase and its homologs in animals and yeast (saccharomyces cerevisiae and schizosaccharomyces pombe) are known to regulate rna processing, signal transduction, and gene expression. however, prmt5 homologs in higher plants have not yet been reported and the biological roles of these proteins in plant development remain elusive. here, using conventional biochemical approaches, we purified a plant histone arg methyltransferase from cauliflower (brassica oleracea) that was nearly identical to atprmt5, an arabidopsis (arabidopsis thaliana) homolog of human prmt5. atprmt5 methylated histone h4, h2a, and myelin basic protein in vitro. western blot using symmetric dimethyl histone h4 arg 3-specific antibody and thin-layer chromatography analysis demonstrated that atprmt5 is a type ii enzyme. mutations in atprmt5 caused pleiotropic developmental defects, including growth retardation, dark green and curled leaves, and flowering locus c (flc)-dependent delayed flowering. therefore, the type ii protein arg methyltransferase atprmt5 is involved in promotion of vegetative growth and flc-dependent flowering time regulation in arabidopsis. |
| WOS关键词 | FLOWERING-LOCUS-C ; HISTONE H3 METHYLATION ; DNA METHYLATION ; SM PROTEINS ; SYMMETRIC DIMETHYLARGININE ; VERNALIZATION ; ARABIDOPSIS ; PRMT5 ; TIME ; FLC |
| WOS研究方向 | Plant Sciences |
| WOS类目 | Plant Sciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000248704800019 |
| 出版者 | AMER SOC PLANT BIOLOGISTS |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2380297 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Cao, Xiaofeng |
| 作者单位 | 1.Chinese Acad Sci, State Key Lab Plant Gen, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Ctr Plant Gene Res, Inst Genet & Dev Biol, Beijing 100101, Peoples R China 3.Shanxi Univ, Coll Life Sci & Technol, Taiyuan 030006, Peoples R China 4.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China |
| 推荐引用方式 GB/T 7714 | Pei, Yanxi,Niu, Lifang,Lu, Falong,et al. Mutations in the type ii protein arginine methyltransferase atprmt5 result in pleiotropic developmental defects in arabidopsis(1[c][oa])[J]. Plant physiology,2007,144(4):1913-1923. |
| APA | Pei, Yanxi.,Niu, Lifang.,Lu, Falong.,Liu, Chunyan.,Zhai, Jixian.,...&Cao, Xiaofeng.(2007).Mutations in the type ii protein arginine methyltransferase atprmt5 result in pleiotropic developmental defects in arabidopsis(1[c][oa]).Plant physiology,144(4),1913-1923. |
| MLA | Pei, Yanxi,et al."Mutations in the type ii protein arginine methyltransferase atprmt5 result in pleiotropic developmental defects in arabidopsis(1[c][oa])".Plant physiology 144.4(2007):1913-1923. |
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来源：中国科学院大学
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