Degranulation of mast cells and histamine release involved in rat pain-related behaviors and edema induced by scorpion buthus martensi karch venom
文献类型：期刊论文
| 作者 | Liu, Tong; Bai, Zhan-Tao; Pang, Xue-Yan; Chai, Zhi-Fang; Jiang, Feng; Ji, Yong-Hua |
| 刊名 | European journal of pharmacology
 |
| 出版日期 | 2007-12-01 |
| 卷号 | 575期号:1-3页码:46-56 |
| 关键词 | Bmk venom Mast cell Histamine Edema Spontaneous pain Thermal hyperalgesia Mechanical hyperalgesia |
| ISSN号 | 0014-2999 |
| DOI | 10.1016/j.ejphar.2007.07.057 |
| 通讯作者 | Ji, yong-hua(yhji@staff.shu.edu.cn) |
| 英文摘要 | In the present study, it was investigated whether the degranulation of mast cells and histamine release were involved in rat pain-related behaviors and edema induced by the venom of scorpion buthus martensi karch (bmk) or not. it was found that the obvious degranulation of mast cells could be triggered in rat hindpaw skin by bmk venom. the chronic degranulation of mast cells using compound 48/80 relieved the spontaneous nociceptive responses, the primary thermal and bilateral mechanical hyperalgesia and the rat paw edema, as well as partially reduced c-fos expression in superficial layers (laminae i-ii) of bilateral spinal cord induced by bmk venom. in addition, individual peripheral co-administration of either 100nmol chlorpheniramine or 100nmol pyrilamine (histamine h-1 receptor antagonist) or 500nmol cimetidine (histamine h, receptor antagonist) and bmk venom suppressed the spontaneous nociceptive responses, partially the primary thermal and bilateral mechanical hyperalgesia and rat paw edema induced by bmk venom. thus, these results suggest that the peripheral cellular incidents of mast cells degranulation and histamine release are involved in bmk venom-induced pain-related behaviors and inflammation. (c) 2007 elsevier b.v. all rights reserved. |
| WOS关键词 | CONTRALATERAL HEAT HYPERALGESIA ; BMK-I ; NERVE INJURY ; SPINAL-CORD ; NEUTROPHIL RECRUITMENT ; INFLAMMATORY MEDIATORS ; THERMAL HYPERALGESIA ; SODIUM-CHANNELS ; FOS EXPRESSION ; CONSCIOUS RAT |
| WOS研究方向 | Pharmacology & Pharmacy |
| WOS类目 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000250801100006 |
| 出版者 | ELSEVIER SCIENCE BV |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2380300 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Ji, Yong-Hua |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Physiol, Grad Sch, Shanghai 200031, Peoples R China 2.Shanghai Univ, Sch Life Sci, Shanghai 200444, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Tong,Bai, Zhan-Tao,Pang, Xue-Yan,et al. Degranulation of mast cells and histamine release involved in rat pain-related behaviors and edema induced by scorpion buthus martensi karch venom[J]. European journal of pharmacology,2007,575(1-3):46-56. |
| APA | Liu, Tong,Bai, Zhan-Tao,Pang, Xue-Yan,Chai, Zhi-Fang,Jiang, Feng,&Ji, Yong-Hua.(2007).Degranulation of mast cells and histamine release involved in rat pain-related behaviors and edema induced by scorpion buthus martensi karch venom.European journal of pharmacology,575(1-3),46-56. |
| MLA | Liu, Tong,et al."Degranulation of mast cells and histamine release involved in rat pain-related behaviors and edema induced by scorpion buthus martensi karch venom".European journal of pharmacology 575.1-3(2007):46-56. |
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来源：中国科学院大学
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