Photodynamic properties of dipeptide-modified hypocrellin b derivatives: the role of tyrosine and tryptophan groups
文献类型：期刊论文
| 作者 | Zeng, Zhanghua; Qiao, Rui; Zhou, Jiahong; Xia, Shengqin; Zhang, Yan; Liu, Yanyan; Chen, Jinrong; Wang, Xuesong; Zhang, Baowen |
| 刊名 | Journal of physical chemistry b
 |
| 出版日期 | 2007-04-12 |
| 卷号 | 111期号:14页码:3742-3749 |
| ISSN号 | 1520-6106 |
| DOI | 10.1021/jp066301y |
| 通讯作者 | Wang, xuesong(xswang@mail.ipc.ac.cn) |
| 英文摘要 | Three long-wavelength absorbing dipeptide-modified hypocrellin b (hb) derivatives, gly-hb, tyr-hb, and trp-hb, were prepared for application in photodynamic therapy (pdt). their abilities to produce free radicals and singlet oxygen were compared in detail with epr technique, and their binding interactions with calf thymus dna (ct dna) were studied by absorption spectra and dna melting temperature measurements. tyr-hb and trp-hb distinguish themselves from gly-hb and hb remarkably by their significantly improved efficiencies to generate semiquinone anion radicals, superoxide anion radicals, and hydroxyl radicals, as well as their affinity to ct dna, as the result of the electron-donating properties and intercalating abilities of tyrosine and tryptophan groups. tyr-hb and trp-hb show remarkably enhanced photodamage capabilities on ct dna than their parent hb in aerobic conditions. moreover, they possess moderate photodamage abilities on ct dna even in anaerobic conditions, indicating the role of type i mechanism in their photodynamic behaviors. |
| WOS关键词 | SEMIQUINONE RADICAL-ANION ; ANTICANCER AGENTS ; PULSE-RADIOLYSIS ; LANTHANUM IONS ; GENERATION ; PHOTOSENSITIZATION ; THERAPY ; O-2(CENTER-DOT-) ; ABSORPTION ; CHELATION |
| WOS研究方向 | Chemistry |
| WOS类目 | Chemistry, Physical |
| 语种 | 英语 |
| WOS记录号 | WOS:000245438700021 |
| 出版者 | AMER CHEMICAL SOC |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2380327 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Wang, Xuesong |
| 作者单位 | 1.Chinese Acad Sci, Tech Inst Phys & Chem, Lab Organ Optoelect Funct Mat & Mol Engn, Beijing 100080, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zeng, Zhanghua,Qiao, Rui,Zhou, Jiahong,et al. Photodynamic properties of dipeptide-modified hypocrellin b derivatives: the role of tyrosine and tryptophan groups[J]. Journal of physical chemistry b,2007,111(14):3742-3749. |
| APA | Zeng, Zhanghua.,Qiao, Rui.,Zhou, Jiahong.,Xia, Shengqin.,Zhang, Yan.,...&Zhang, Baowen.(2007).Photodynamic properties of dipeptide-modified hypocrellin b derivatives: the role of tyrosine and tryptophan groups.Journal of physical chemistry b,111(14),3742-3749. |
| MLA | Zeng, Zhanghua,et al."Photodynamic properties of dipeptide-modified hypocrellin b derivatives: the role of tyrosine and tryptophan groups".Journal of physical chemistry b 111.14(2007):3742-3749. |
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来源：中国科学院大学
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