The differential expression and regulation of igfbp-7 ' in the process of embryo implantation in rats
文献类型：期刊论文
| 作者 | Xia Hong-Fei; Sun Jing; Yang Ying; Peng Jing-Pian |
| 刊名 | Progress in biochemistry and biophysics
 |
| 出版日期 | 2007-03-01 |
| 卷号 | 34期号:3页码:267-274 |
| 关键词 | Igfbp-7 ' Sd rat Uterus Embryo implantation |
| ISSN号 | 1000-3282 |
| 通讯作者 | Peng jing-pian(pengjp@ioz.ac.cn) |
| 英文摘要 | Igfbp-7 plays an important role in the process of human pregnancy. however, it is not found in rats. in previous study, suppression subtractive hybridization (ssh) was utilized to analyse differentially expressed gene between pre-implantation period and implantation period and igfbp-7 was identified as a gene differentially expressed. temporo-spatial expression pattern of partial igfbp-7 cdna sequence(cds 531 similar to 928 nt, igfbp-7') in early pregnancy was detected by northern blot and in situ hybridization. rt-pcr was used to analyse igfbp-7' mrna expression in multiple tissue and uterus of pseudopregnancy, artificial decidualization and delayed-implantation. results indicated that igfbp-7' mrna expression level began to increase in the day 5 of pregnancy, the expression level during day 5.5 and 6 is higher than pre-implantation period. igfbp-7' mrna was mainly located in luminal epithelium and gland epithelium. the expression of igfbp-7' mrna have not tissue-specific and was detected in hypothalamus, pituitary, uterus, ovary, heart, liver, spleen, lung, kidney and so on. the expression of igfbp-7' mrna was not significantly different in uterus of pseudopregnancy and artificial decidualization, and significantly increased in the uterus of delayed-implantation. collectively, these results suggest that igfbp-7' expression increase is mainly induced by blastocyst, not decidualization during the window of implantation, which may be beneficial to embryo implantation in the early of pregnancy in rats. |
| WOS关键词 | PROTEIN-RELATED PROTEIN-1 ; BINDING-PROTEINS ; IGF SYSTEM ; GROWTH ; CELLS ; CANCER ; SUPERFAMILY ; GENES |
| WOS研究方向 | Biochemistry & Molecular Biology ; Biophysics |
| WOS类目 | Biochemistry & Molecular Biology ; Biophysics |
| 语种 | 英语 |
| WOS记录号 | WOS:000245014900007 |
| 出版者 | SCIENCE CHINA PRESS |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2380390 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Peng Jing-Pian |
| 作者单位 | 1.Chinese Acad Sci, State Key Lab Reprod Biol, Inst Zool, Beijing 100080, Peoples R China 2.Grad Univ, Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xia Hong-Fei,Sun Jing,Yang Ying,et al. The differential expression and regulation of igfbp-7 ' in the process of embryo implantation in rats[J]. Progress in biochemistry and biophysics,2007,34(3):267-274. |
| APA | Xia Hong-Fei,Sun Jing,Yang Ying,&Peng Jing-Pian.(2007).The differential expression and regulation of igfbp-7 ' in the process of embryo implantation in rats.Progress in biochemistry and biophysics,34(3),267-274. |
| MLA | Xia Hong-Fei,et al."The differential expression and regulation of igfbp-7 ' in the process of embryo implantation in rats".Progress in biochemistry and biophysics 34.3(2007):267-274. |
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来源：中国科学院大学
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