Streptococcus oligofermentans inhibits streptococcus mutans through conversion of lactic acid into inhibitory h2o2: a possible counteroffensive strategy for interspecies competition
文献类型：期刊论文
| 作者 | Tong, Huichun; Chen, Wei; Merritt, Justin; Qi, Fengxia; Shi, Wenyuan; Dong, Xiuzhu |
| 刊名 | Molecular microbiology
 |
| 出版日期 | 2007-02-01 |
| 卷号 | 63期号:3页码:872-880 |
| ISSN号 | 0950-382X |
| DOI | 10.1111/j.1365-2958.2006.05546.x |
| 通讯作者 | Dong, xiuzhu(dongxz@sun.im.ac.cn) |
| 英文摘要 | The oral microbial flora contains over 500 different microbial species that often interact as a means to compete for limited space and nutritional resources. streptococcus mutans, a major caries-causing pathogen, is a species which tends to interact competitively with other species in the oral cavity, largely due to its ability to generate copious quantities of the toxic metabolite, lactic acid. however, during a recent clinical study, we discovered a novel oral streptococcal species, streptococcus oligofermentans, whose abundance appeared to be inversely correlated with that of s. mutans within dental plaque samples and thus suggested a possible antagonistic relationship with s. mutans. in this study, we used a defined in vitro interspecies interaction assay to confirm that s. oligofermentans was indeed able to inhibit the growth of s. mutans. interestingly, this inhibitory effect was relatively specific to s. mutans and was actually enhanced by the presence of lactic acid. biochemical analyses revealed that s. oligofermentans inhibited the growth of s. mutans via the production of hydrogen peroxide with lactic acid as the substrate. further genetic and molecular analysis led to the discovery of the lactate oxidase (lox) gene of s. oligofermentans as responsible for this biological activity. consequently, the lox mutant of s. oligofermentans also showed dramatically reduced inhibitory effects against s. mutans and also exhibited greatly impaired growth in the presence of the lactate produced by s. mutans. these data indicate that s. oligofermentans possesses the capacity to convert its competitor's main 'weapon' (lactic acid) into an inhibitory chemical (h2o2) in order to gain a competitive growth advantage. this fascinating ability may be an example of a counteroffensive strategy used during chemical warfare within the oral microbial community. |
| WOS关键词 | GROUP-A STREPTOCOCCI ; GROUP-I STRAIN ; BACTERIAL DIVERSITY ; BIOSYNTHESIS GENES ; HYDROGEN-PEROXIDE ; MUTACIN-I ; SP-NOV. ; PURIFICATION ; SANGUINIS ; LACTATE |
| WOS研究方向 | Biochemistry & Molecular Biology ; Microbiology |
| WOS类目 | Biochemistry & Molecular Biology ; Microbiology |
| 语种 | 英语 |
| WOS记录号 | WOS:000243507700020 |
| 出版者 | BLACKWELL PUBLISHING |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2380392 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Dong, Xiuzhu |
| 作者单位 | 1.Chinese Acad Sci, Inst Microbiol, State Key Lab Microbial Resources, Beijing 100080, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100080, Peoples R China 3.Univ Calif Los Angeles, Sch Dent, Los Angeles, CA 90095 USA 4.Univ Calif Los Angeles, Dept Microbiol Immunol & Mol Genet, Los Angeles, CA 90095 USA |
| 推荐引用方式 GB/T 7714 | Tong, Huichun,Chen, Wei,Merritt, Justin,et al. Streptococcus oligofermentans inhibits streptococcus mutans through conversion of lactic acid into inhibitory h2o2: a possible counteroffensive strategy for interspecies competition[J]. Molecular microbiology,2007,63(3):872-880. |
| APA | Tong, Huichun,Chen, Wei,Merritt, Justin,Qi, Fengxia,Shi, Wenyuan,&Dong, Xiuzhu.(2007).Streptococcus oligofermentans inhibits streptococcus mutans through conversion of lactic acid into inhibitory h2o2: a possible counteroffensive strategy for interspecies competition.Molecular microbiology,63(3),872-880. |
| MLA | Tong, Huichun,et al."Streptococcus oligofermentans inhibits streptococcus mutans through conversion of lactic acid into inhibitory h2o2: a possible counteroffensive strategy for interspecies competition".Molecular microbiology 63.3(2007):872-880. |
入库方式： iSwitch采集
来源：中国科学院大学
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。