Activation of demineralized bone matrix by genetically engineered human bone morphogenetic protein-2 with a collagen binding domain derived from von willebrand factor propolypeptide
文献类型：期刊论文
| 作者 | Chen, Bing; Lin, Hang; Zhao, Yannan; Wang, Bin; Zhao, Yanhong; Liu, Yunpeng; Liu, Zhonghao; Dai, Jianwu |
| 刊名 | Journal of biomedical materials research part a
 |
| 出版日期 | 2007-02-01 |
| 卷号 | 80a期号:2页码:428-434 |
| 关键词 | Bone regeneration Bone scaffold Targeting system Growth factor Ectopic bone formation |
| ISSN号 | 1549-3296 |
| DOI | 10.1002/jbm.a.30900 |
| 通讯作者 | Dai, jianwu(jwdai@genetics.ac.cn) |
| 英文摘要 | There is a large demand for new bone regeneration to restore the function during bone injuries. bone filling materials are important in bone tissue restoration. in this study, the demineralized bone matrix (dbm) was activated with the engineering human bone morphogenetic protein-2 (bmp-2). to enhance the binding of bmp-2 to the dbm scaffolds, a collagen-binding peptide was fused to the n-terminal of bmp-2. the in vitro results showed that the engineered collagen-targeted bmp-2 (rhbmp2-v) bound to dbm scaffolds specifically and the rhbmp2-v had increased alkaline phosphatase activity in c2c12 cells. in vivo, the dbm scaffolds impregnated with rhbmp2-v showed greater effect on ectopic bone formation. our data suggested that the collagen-based bmp-2 targeting bone repair system had greater bone inducing ability than dbm loaded with regular bmp-2. (c) 2006 wiley periodicals, inc. |
| WOS关键词 | GROWTH-FACTOR-BETA ; GRAFT SUBSTITUTES ; DIFFERENTIATION PATHWAY ; FUSION PROTEIN ; SPINAL-FUSION ; RENATURATION ; MODEL ; REGENERATION ; EXPRESSION ; CELLS |
| WOS研究方向 | Engineering ; Materials Science |
| WOS类目 | Engineering, Biomedical ; Materials Science, Biomaterials |
| 语种 | 英语 |
| WOS记录号 | WOS:000243455300018 |
| 出版者 | WILEY-LISS |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2380441 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Dai, Jianwu |
| 作者单位 | 1.Chinese Acad Sci, Key Lab Mol & Dev Biol, Inst Genet & Dev Biol, Beijing 100080, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100080, Peoples R China 3.Yantaishan Hosp, Dept Orthoped, Shandong 264001, Peoples R China 4.Yantai Stomatol Hosp, Nobel Biocare Yantai Dent Implant Ctr, Shandong 264001, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Bing,Lin, Hang,Zhao, Yannan,et al. Activation of demineralized bone matrix by genetically engineered human bone morphogenetic protein-2 with a collagen binding domain derived from von willebrand factor propolypeptide[J]. Journal of biomedical materials research part a,2007,80a(2):428-434. |
| APA | Chen, Bing.,Lin, Hang.,Zhao, Yannan.,Wang, Bin.,Zhao, Yanhong.,...&Dai, Jianwu.(2007).Activation of demineralized bone matrix by genetically engineered human bone morphogenetic protein-2 with a collagen binding domain derived from von willebrand factor propolypeptide.Journal of biomedical materials research part a,80a(2),428-434. |
| MLA | Chen, Bing,et al."Activation of demineralized bone matrix by genetically engineered human bone morphogenetic protein-2 with a collagen binding domain derived from von willebrand factor propolypeptide".Journal of biomedical materials research part a 80a.2(2007):428-434. |
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来源：中国科学院大学
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