Preparation and controlled drug release properties of magnetic microcapsules
文献类型：期刊论文
| 作者 | Li Lin-Lin1,2; Chen Dong1; Ding Ming-Hui1; Tang Fang-Qiong1; Meng Xian-Wei1; Ren Jun1; Zhang Lin1 |
| 刊名 | Acta physico-chimica sinica
 |
| 出版日期 | 2007-12-01 |
| 卷号 | 23期号:12页码:1969-1973 |
| 关键词 | Microcapsule Magnetic targeting Controlled drug release Magnetic hollow spheres Ph-responsive Chitosan |
| ISSN号 | 1000-6818 |
| DOI | 10.3866/pku.whxb20071226 |
| 通讯作者 | Tang fang-qiong(tangfq@mail.ipc.ac.cn) |
| 英文摘要 | Magnetic chitosan-alginate microcapsules were prepared via emulsion-gel method. fe3o4 magnetic hollow spheres were capsulated into the microcapsules, which endowed the microcapsules with magnetic targeting properties. cefradine was used as model drug to study the properties of the microcapsules including drug content, encapsulation efficiency, and controlled drug release. the results showed that with the increasing of initial drug concentration, the drug content increased, but the encapsulation efficiency decreased. the microcapsules exhibited sustained release of the drug in all media and the release rate could be regulated by the ph value: in simulated gastric fluid, the release rate was greatly decreased, and in simulated body fluid and intestinal fluid, the microcapsules exhibited a constant release in 50 h with different release rates. under an external magnetic field, the microcapsules showed fine magnetic response properties, which provided possibility for magnetic targeting drug delivery. |
| WOS关键词 | ALGINATE-CHITOSAN ; ORAL DELIVERY ; IN-VITRO ; ENCAPSULATION ; PERSPECTIVES ; DOXORUBICIN ; INSULIN ; BEADS ; VIVO |
| WOS研究方向 | Chemistry |
| WOS类目 | Chemistry, Physical |
| 语种 | 英语 |
| WOS记录号 | WOS:000251812900027 |
| 出版者 | PEKING UNIV PRESS |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2380479 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Tang Fang-Qiong |
| 作者单位 | 1.Chinese Acad Sci, Tech Inst Phys & Chem, Beijing 100080, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li Lin-Lin,Chen Dong,Ding Ming-Hui,et al. Preparation and controlled drug release properties of magnetic microcapsules[J]. Acta physico-chimica sinica,2007,23(12):1969-1973. |
| APA | Li Lin-Lin.,Chen Dong.,Ding Ming-Hui.,Tang Fang-Qiong.,Meng Xian-Wei.,...&Zhang Lin.(2007).Preparation and controlled drug release properties of magnetic microcapsules.Acta physico-chimica sinica,23(12),1969-1973. |
| MLA | Li Lin-Lin,et al."Preparation and controlled drug release properties of magnetic microcapsules".Acta physico-chimica sinica 23.12(2007):1969-1973. |
入库方式： iSwitch采集
来源：中国科学院大学
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。