Computer-aided target optimization for traditional Chinese medicine by ultra-performance liquid chromatography
文献类型：期刊论文
| 作者 | Jin, Gaowa1; Xue, Xingya1; Zhang, Feifang1; Jin, Yu2; Liang, Xinmiao1,2 |
| 刊名 | talanta
 |
| 出版日期 | 2009-04-15 |
| 卷号 | 78期号:1页码:278-283 |
| 关键词 | Target optimization Computer-aided software Moved overlapping separation ranging map Traditional Chinese medicine Ultra-performance liquid chromatography |
| 产权排序 | 1;1 |
| 通讯作者 | 梁鑫淼 |
| 英文摘要 | a new strategy of target optimization was developed for resolving the separation problems of complex samples. computer-aided target optimization for separation of complex samples by ultra-performance liquid chromatography (uplc) was studied. taking traditional chinese medicine (tcm) (rhizoma coptidis) as an example, separation conditions of target compounds - overlapping peaks and all components - were optimized based on moved overlapping separation ranging map(osrm) and artificially intervention. after calculating retention parameters and peak shape parameters of the target peaks, the optimization was operated in an emulational picture through the computer without further experiments. the emulational chromatogram was proved to be authentic by the estimated values, which were almost identical to experimental results. the method was very helpful for obtaining the satisfied separation conditions of target compounds rapidly and efficiently. (c) 2008 elsevier b.v. all rights reserved. |
| WOS标题词 | science & technology ; physical sciences |
| 类目[WOS] | chemistry, analytical |
| 研究领域[WOS] | chemistry |
| 关键词[WOS] | restricted multiparameter approach ; flight mass-spectrometry ; mobile-phase ; simulation ; separation ; design ; uplc ; time |
| 收录类别 | SCI |
| 原文出处 | true |
| 语种 | 英语 |
| WOS记录号 | WOS:000263634700043 |
| 公开日期 | 2010-11-30 |
| 源URL | [http://159.226.238.44/handle/321008/101601]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China 2.E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jin, Gaowa,Xue, Xingya,Zhang, Feifang,et al. Computer-aided target optimization for traditional Chinese medicine by ultra-performance liquid chromatography[J]. talanta,2009,78(1):278-283. |
| APA | Jin, Gaowa,Xue, Xingya,Zhang, Feifang,Jin, Yu,&Liang, Xinmiao.(2009).Computer-aided target optimization for traditional Chinese medicine by ultra-performance liquid chromatography.talanta,78(1),278-283. |
| MLA | Jin, Gaowa,et al."Computer-aided target optimization for traditional Chinese medicine by ultra-performance liquid chromatography".talanta 78.1(2009):278-283. |
入库方式： OAI收割
来源：大连化学物理研究所
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