Feedback control of mkp-1 expression by p38
文献类型：期刊论文
| 作者 | Hu, Jun-Hao; Chen, Ting; Zhuang, Zi-Heng; Kong, Ling; Yu, Ming-Can; Liu, Yusen; Zang, Jing-Wu; Ge, Bao-Xue |
| 刊名 | Cellular signalling
 |
| 出版日期 | 2007-02-01 |
| 卷号 | 19期号:2页码:393-400 |
| 关键词 | Mkp-1 P38 Tlrs Pgn Lps tolerance Innate immunity |
| ISSN号 | 0898-6568 |
| DOI | 10.1016/j.cellsig.2006.07.010 |
| 通讯作者 | Ge, bao-xue(gebaoxue@sibs.ac.cn) |
| 英文摘要 | Mitogen-activated protein (map) kinases play a critical role in innate immune responses to microbial infection through eliciting the biosynthesis of proinflammatory cytokines. map phosphatases (mkp)-1 is an archetypical member of the dual-specificity phosphatase family that deactivates map kinases. induction of mkp-1 has been implicated in attenuating the lipopolysaccharide (lps) and peptidoglycan (pgn) responses, but how the expression of the mkp-1 is regulated is still not fully understood. here, we show that inhibition of p38 map kinase by specific inhibitor sb 203580 or rna interference (rnai) markedly reduced the expression of mkp-1 in lps or pgn-treated macrophages, which is correlated with prolonged activation of p38 and jnk. depletion of mapkap kinase 2 (mk2), a downstream substrate of p38, by rnai also inhibited the expression of mkp-1. the mrna level of mkp-1 is not affected by inhibition of p38, but the expression of mkp-1 is inhibited by treatment of cycloheximide. thus, p38 mapk plays a critical role in mediating expression of mkp-1 at a post-transcriptional level. furthermore, inhibition of p38 by sb 203580 prevented the expression of mkp-1 in lps-tolerized macrophages, restored the activation of map kinases after lps restimulation. these results indicate a critical role of p38-mk2-dependent induction of mkp-1 in innate immune responses. (c) 2006 elsevier inc. all rights reserved. |
| WOS关键词 | ACTIVATED PROTEIN-KINASE ; INNATE IMMUNE-RESPONSES ; TOLL-LIKE RECEPTORS ; LIPOPOLYSACCHARIDE-STIMULATED MACROPHAGES ; PROINFLAMMATORY CYTOKINE BIOSYNTHESIS ; PHOSPHATASE-1 DEGRADATION ; MAPK PHOSPHATASE-1 ; GENE-EXPRESSION ; HEAT-SHOCK ; TNF-ALPHA |
| WOS研究方向 | Cell Biology |
| WOS类目 | Cell Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000243715000019 |
| 出版者 | ELSEVIER SCIENCE INC |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2380600 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Ge, Bao-Xue |
| 作者单位 | 1.Chinese Acad Sci, Inst Hlth Sci, Shanghai 200025, Peoples R China 2.Shanghai Jiao Tong Univ, Sch Med, Joint Immunol Lab, Hlth Sci Ctr, Shanghai 200025, Peoples R China 3.Shanghai Jiao Tong Univ, Sch Med, Shanghai Inst Immunol, Shanghai 200025, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai, Peoples R China 5.Chinese Acad Sci, Grad Sch, Shanghai, Peoples R China 6.Shanghai Univ, E Inst, Shanghai 200025, Peoples R China 7.Ohio State Univ, Childrens Res Inst, Dept Pediat, Columbus, OH 43205 USA |
| 推荐引用方式 GB/T 7714 | Hu, Jun-Hao,Chen, Ting,Zhuang, Zi-Heng,et al. Feedback control of mkp-1 expression by p38[J]. Cellular signalling,2007,19(2):393-400. |
| APA | Hu, Jun-Hao.,Chen, Ting.,Zhuang, Zi-Heng.,Kong, Ling.,Yu, Ming-Can.,...&Ge, Bao-Xue.(2007).Feedback control of mkp-1 expression by p38.Cellular signalling,19(2),393-400. |
| MLA | Hu, Jun-Hao,et al."Feedback control of mkp-1 expression by p38".Cellular signalling 19.2(2007):393-400. |
入库方式： iSwitch采集
来源：中国科学院大学
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。