Intrathecal injection of glutamate receptor antagonists/agonist selectively attenuated rat pain-related behaviors induced by the venom of scorpion buthus martensi karsch
文献类型：期刊论文
| 作者 | Liu, Tong2; Pang, Xue-Yan1; Bai, Zhan-Tao2; Chai, Zhi-Fang2; Jiang, Feng1; Ji, Yong-Hua1 |
| 刊名 | Toxicon
 |
| 出版日期 | 2007-12-15 |
| 卷号 | 50期号:8页码:1073-1084 |
| 关键词 | Bmk venom Glutamate receptors Spontaneous pain Thermal hyperalgesia Mechanical hyperalgesia |
| ISSN号 | 0041-0101 |
| DOI | 10.1016/j.toxicon.2007.07.012 |
| 通讯作者 | Ji, yong-hua(yhji@server.shcnc.ac.cn) |
| 英文摘要 | The present study investigated the involvement of spinal glutamate receptors in the induction and maintenance of the pain-related behaviors induced by the venom of scorpion buthus martensi karsch (bmk). (5r,10s)-(+)-5-methyl-10, 11-dihydro-5h-dibenzo[a,d]-cyclohepten-5-10-imine hydrogen maleate (mk-801; 40 nmol; a non-competitive nmda receptor antagonist), 6-cyano-7-nitroquinoxaline-2,3-dione (cnqx; 40 nmol; a non-nmda receptor antagonist), dl-amino-3-phosphonopropionic acid (dl-ap3; 100 nmol; a group i metabotropic glutamate receptor antagonist) and 4-aminopyrrolidine-2,4-dicarboxylate (apdc; 100 nmol; a group 11 metabotropic glutamate receptor agonist) were employed. on intrathecal injection of glutamate receptor antagonists/agonist before bmk venom administration by 10 min, bmk venom-induced spontaneous nociceptive responses could be suppressed by all tested agents. primary thermal hyperalgesia could be inhibited by mk-801 and dl-ap3, while bilateral mechanical hyperalgesia could be inhibited by cnqx and dl-ap3 and contralateral mechanical hyperalgesia could be inhibited by apdc. on intrathecal injection of glutamate receptor antagonists/agonist after bmk venom injection by 4.5 h, primary thermal hyperalgesia could be partially reversed by all tested agents, while bilateral mechanical hyperalgesia could only be inhibited by apdc. the results suggest that the role of spinal glutamate receptors may be different on the various manifestations of bmk venom-induced pain-related behaviors. (c) 2007 elsevier ltd. all rights reserved. |
| WOS关键词 | INDUCED TISSUE-INJURY ; DORSAL-HORN NEURONS ; PROTEIN-KINASE-C ; SPINAL-CORD ; FORMALIN TEST ; NITRIC-OXIDE ; BMK VENOM ; NON-NMDA ; MECHANICAL HYPERALGESIA ; PERSISTENT NOCICEPTION |
| WOS研究方向 | Pharmacology & Pharmacy ; Toxicology |
| WOS类目 | Pharmacology & Pharmacy ; Toxicology |
| 语种 | 英语 |
| WOS记录号 | WOS:000251557900007 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2380925 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Ji, Yong-Hua |
| 作者单位 | 1.Shanghai Univ, Sch Life Sci, Shanghai 200444, Peoples R China 2.Chinese Acad Sci, Inst Biol Sci, Grad Sch, Inst Physiol, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Tong,Pang, Xue-Yan,Bai, Zhan-Tao,et al. Intrathecal injection of glutamate receptor antagonists/agonist selectively attenuated rat pain-related behaviors induced by the venom of scorpion buthus martensi karsch[J]. Toxicon,2007,50(8):1073-1084. |
| APA | Liu, Tong,Pang, Xue-Yan,Bai, Zhan-Tao,Chai, Zhi-Fang,Jiang, Feng,&Ji, Yong-Hua.(2007).Intrathecal injection of glutamate receptor antagonists/agonist selectively attenuated rat pain-related behaviors induced by the venom of scorpion buthus martensi karsch.Toxicon,50(8),1073-1084. |
| MLA | Liu, Tong,et al."Intrathecal injection of glutamate receptor antagonists/agonist selectively attenuated rat pain-related behaviors induced by the venom of scorpion buthus martensi karsch".Toxicon 50.8(2007):1073-1084. |
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来源：中国科学院大学
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