中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Synthetic improvements in the preparation of clopidogrel

文献类型:期刊论文

作者Wang, Lixin; Shen, Jianfen; Tang, Yi; Chen, Yi; Wang, Wen; Cai, Zegui; Du, Zhenjun
刊名Organic process research & development
出版日期2007-05-01
卷号11期号:3页码:487-489
ISSN号1083-6160
DOI10.1021/op700025d
通讯作者Wang, lixin(wlxioc@cioc.ac.cn)
英文摘要Synthetic improvements in the preparation of clopidogrel are described. the synthesis was accomplished in four steps or one-pot in above 70% overall yield. the process featured ptc catalyzed alkaline hydrolysis of the key intermediate 2-(2-chlorophenyl)-2-(6,7-dihydrothieno[3,2-c]pyridin-5(4h)-yl)acetonitrile and highly effective kinetic resolution of racemic clopidogrel using l-camphorsulphonic acid in toluene and has been successfully used in a 50-kg pilot test.
WOS关键词DERIVATIVES ; ACTIVATION
WOS研究方向Chemistry
WOS类目Chemistry, Applied ; Chemistry, Organic
语种英语
WOS记录号WOS:000246570400026
出版者AMER CHEMICAL SOC
URI标识http://www.irgrid.ac.cn/handle/1471x/2381209
专题中国科学院大学
通讯作者Wang, Lixin
作者单位1.Chinese Acad Sci, Chengdu Inst Organ Chem, Union Lab Asymmetr Synth, Key Lab Asymmetr Synth & Chirotechnol Sichuan Pro, Chengdu 610041, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
推荐引用方式
GB/T 7714
Wang, Lixin,Shen, Jianfen,Tang, Yi,et al. Synthetic improvements in the preparation of clopidogrel[J]. Organic process research & development,2007,11(3):487-489.
APA Wang, Lixin.,Shen, Jianfen.,Tang, Yi.,Chen, Yi.,Wang, Wen.,...&Du, Zhenjun.(2007).Synthetic improvements in the preparation of clopidogrel.Organic process research & development,11(3),487-489.
MLA Wang, Lixin,et al."Synthetic improvements in the preparation of clopidogrel".Organic process research & development 11.3(2007):487-489.

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来源:中国科学院大学

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