Synthetic improvements in the preparation of clopidogrel
文献类型：期刊论文
| 作者 | Wang, Lixin; Shen, Jianfen; Tang, Yi; Chen, Yi; Wang, Wen; Cai, Zegui; Du, Zhenjun |
| 刊名 | Organic process research & development
 |
| 出版日期 | 2007-05-01 |
| 卷号 | 11期号:3页码:487-489 |
| ISSN号 | 1083-6160 |
| DOI | 10.1021/op700025d |
| 通讯作者 | Wang, lixin(wlxioc@cioc.ac.cn) |
| 英文摘要 | Synthetic improvements in the preparation of clopidogrel are described. the synthesis was accomplished in four steps or one-pot in above 70% overall yield. the process featured ptc catalyzed alkaline hydrolysis of the key intermediate 2-(2-chlorophenyl)-2-(6,7-dihydrothieno[3,2-c]pyridin-5(4h)-yl)acetonitrile and highly effective kinetic resolution of racemic clopidogrel using l-camphorsulphonic acid in toluene and has been successfully used in a 50-kg pilot test. |
| WOS关键词 | DERIVATIVES ; ACTIVATION |
| WOS研究方向 | Chemistry |
| WOS类目 | Chemistry, Applied ; Chemistry, Organic |
| 语种 | 英语 |
| WOS记录号 | WOS:000246570400026 |
| 出版者 | AMER CHEMICAL SOC |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2381209 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Wang, Lixin |
| 作者单位 | 1.Chinese Acad Sci, Chengdu Inst Organ Chem, Union Lab Asymmetr Synth, Key Lab Asymmetr Synth & Chirotechnol Sichuan Pro, Chengdu 610041, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Lixin,Shen, Jianfen,Tang, Yi,et al. Synthetic improvements in the preparation of clopidogrel[J]. Organic process research & development,2007,11(3):487-489. |
| APA | Wang, Lixin.,Shen, Jianfen.,Tang, Yi.,Chen, Yi.,Wang, Wen.,...&Du, Zhenjun.(2007).Synthetic improvements in the preparation of clopidogrel.Organic process research & development,11(3),487-489. |
| MLA | Wang, Lixin,et al."Synthetic improvements in the preparation of clopidogrel".Organic process research & development 11.3(2007):487-489. |
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来源：中国科学院大学
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