Suppression by intrathecal bmk it2 on rat spontaneous pain behaviors and spinal c-fos expression induced by formalin
文献类型：期刊论文
| 作者 | Bai, Zhan-Tao; Liu, Tong; Pang, Xue-Yan; Chai, Zhi-Fang; Ji, Yong-Hua |
| 刊名 | Brain research bulletin
 |
| 出版日期 | 2007-07-12 |
| 卷号 | 73期号:4-6页码:248-253 |
| 关键词 | Bmk it2 Sodium channel modulator Intrathecal injection Formalin Spontaneous pain C-fos expression |
| ISSN号 | 0361-9230 |
| DOI | 10.1016/j.brainresbull.2007.03.007 |
| 通讯作者 | Ji, yong-hua(yhji@staff.shu.edu.cn) |
| 英文摘要 | The central anti-nociception of bmk it2, a sodium channel modulator from scorpion buthus martensi karsh (bmk) was investigated in this study. it was found that the formalin-induced rat spontaneous flinches and spinal c-fos expression could be significantly suppressed by intrathecal bmk it2 pre- or post-formalin injection in a dose-dependent manner. the time course of inhibitory effect exerted by intrathecal bmk it2 on spontaneous flinches was longer in the pre-treatment group than in post-treatment group. this was consistent with the stronger suppression on spinal c-fos expression exerted by intrathecal bmk it2 pre-treatment. in addition, the suppression by intrathecal bmk it2 on formalin-induced c-fos expression in superficial laminae was more significant than that in deeper laminae. these results indicate that bmk it2 can induce central anti-nociceptive response and might thus be a valuable molecular tool for the understanding of pain mechanisms. (c) 2007 elsevier inc. all rights reserved. |
| WOS关键词 | BUTHUS-MARTENSI KARSCH ; DORSAL HORN NEURONS ; GATED NA+ CURRENTS ; SCORPION ACTIVE POLYPEPTIDE ; ROOT GANGLION NEURONS ; SUBCUTANEOUS FORMALIN ; POSSIBLE MECHANISM ; SODIUM-CHANNELS ; NERVOUS-SYSTEM ; NOCICEPTIVE RESPONSE |
| WOS研究方向 | Neurosciences & Neurology |
| WOS类目 | Neurosciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000247775000007 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2381212 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Ji, Yong-Hua |
| 作者单位 | 1.Shanghai Univ, Sch Life Sci, Shanghai 200444, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Physiol, Grad Sch, Shanghai 200031, Peoples R China 3.Yanan Univ, Coll Life Sci, Yanan 716000, Peoples R China |
| 推荐引用方式 GB/T 7714 | Bai, Zhan-Tao,Liu, Tong,Pang, Xue-Yan,et al. Suppression by intrathecal bmk it2 on rat spontaneous pain behaviors and spinal c-fos expression induced by formalin[J]. Brain research bulletin,2007,73(4-6):248-253. |
| APA | Bai, Zhan-Tao,Liu, Tong,Pang, Xue-Yan,Chai, Zhi-Fang,&Ji, Yong-Hua.(2007).Suppression by intrathecal bmk it2 on rat spontaneous pain behaviors and spinal c-fos expression induced by formalin.Brain research bulletin,73(4-6),248-253. |
| MLA | Bai, Zhan-Tao,et al."Suppression by intrathecal bmk it2 on rat spontaneous pain behaviors and spinal c-fos expression induced by formalin".Brain research bulletin 73.4-6(2007):248-253. |
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来源：中国科学院大学
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