Comparative analysis of two-component signal transduction system in two streptomycete genomes
文献类型：期刊论文
| 作者 | Wei, Wu; Wang, Weihua; Cao, Zhiwei; Yu, Hong; Wang, Xiaojing; Zhao, Jing; Tan, Hao; Xu, Hao; Jiang, Weihong; Li, Yixue |
| 刊名 | Acta biochimica et biophysica sinica
 |
| 出版日期 | 2007-05-01 |
| 卷号 | 39期号:5页码:317-325 |
| 关键词 | Streptomyces Two-component system Cross-talk Phylogenetic analysis |
| ISSN号 | 1672-9145 |
| DOI | 10.1111/j.1745-7270.2007.00282.x |
| 通讯作者 | Jiang, weihong(whjiang@sibs.ac) |
| 英文摘要 | Species of the genus streptomyces are major bacteria responsible for producing most natural antibiotics. streptomyces coelicolor a3(2) and streptomyces avermitilis were sequenced in 2002 and 2003, respectively. two-component signal transduction systems (tcss), consisting of a histidine sensor kinase (sk) and a cognate response regulator (rr), form the most common mechanism of transmembrane signal transduction in prokaryotes. tcss in s. coelicolor a3(2) have been analyzed in detail. here, we identify and classify the sk and rr of s. avermitilis and compare the tcss with those of s. coelicolor a3(2) by computational approaches. phylogenetic analysis of the cognate sk-rr pairs of the two species indicated that the cognate sk-rr pairs fall into four classes according to the distribution of their orthologs in other organisms. in addition to the cognate sk-rr pairs, some potential partners of non-cognate sk-rr were found, including those of unpaired sk and orphan rr and the cross-talk between different components in either strain. our study provides new clues for further exploration of the molecular regulation mechanism of streptomycetes with industrial importance. |
| WOS关键词 | BACILLUS-SUBTILIS ; HISTIDINE KINASES ; ESCHERICHIA-COLI ; COELICOLOR A3(2) ; PROTEINS ; SEQUENCE ; DOMAIN ; SENSORS |
| WOS研究方向 | Biochemistry & Molecular Biology ; Biophysics |
| WOS类目 | Biochemistry & Molecular Biology ; Biophysics |
| 语种 | 英语 |
| WOS记录号 | WOS:000246680800002 |
| 出版者 | BLACKWELL PUBLISHING |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2381271 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Jiang, Weihong |
| 作者单位 | 1.Chinese Acad Sci, Grad Sch, Shanghai Inst Biol Sci, Key Lab Syst Biol,Bioinformat Ctr, Shanghai 200031, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Biol Sci, Grad Sch, Inst Plant Physiol & Ecol,Lab Mol Microbiol, Shanghai 200032, Peoples R China 3.Shanghai Ctr Bioinformat Technol, Shanghai 200235, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wei, Wu,Wang, Weihua,Cao, Zhiwei,et al. Comparative analysis of two-component signal transduction system in two streptomycete genomes[J]. Acta biochimica et biophysica sinica,2007,39(5):317-325. |
| APA | Wei, Wu.,Wang, Weihua.,Cao, Zhiwei.,Yu, Hong.,Wang, Xiaojing.,...&Li, Yixue.(2007).Comparative analysis of two-component signal transduction system in two streptomycete genomes.Acta biochimica et biophysica sinica,39(5),317-325. |
| MLA | Wei, Wu,et al."Comparative analysis of two-component signal transduction system in two streptomycete genomes".Acta biochimica et biophysica sinica 39.5(2007):317-325. |
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来源：中国科学院大学
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