Cytoplasm-localized sirt1 enhances apoptosis
文献类型：期刊论文
| 作者 | Jin, Qihuang; Yan, Tingting; Ge, Xinjian; Sun, Cheng; Shi, Xianglin; Zhai, Qiwei |
| 刊名 | Journal of cellular physiology
 |
| 出版日期 | 2007-10-01 |
| 卷号 | 213期号:1页码:88-97 |
| ISSN号 | 0021-9541 |
| DOI | 10.1002/jcp.21091 |
| 通讯作者 | Zhai, qiwei(qwzhai@sibs.ac.cn) |
| 英文摘要 | In general, sirt1 is localized in nuclei. here, we showed that endogenous and exogenous sirt1 were both able to partially localize in cytoplasm in certain cell lines, and cytoplasm-localized sirt1 was associated with apoptosis and led to increased sensitivity to apoptosis. furthermore, we demonstrated that translocation of nucleus-localized sirt1 from nuclei to cytoplasm was the main pathway leading to localization of sirt1 in cytoplasm. in hela cells, wild type sirt1 was completely localized in nuclei. by truncation of two predicted nuclear localization signals or fusion with an exogenous nuclear export signal, sirt1 was partially localized in cytoplasm of hela cells and resulted in increased sensitivity to apoptosis. the apoptosis enhanced by cytoplasm-localized sirt1 was independent of its deacetylase activity, but dependent on caspases. sirt1 was distributed in cytoplasm at metaphase during mitosis, and overexpression of sirt1 significantly augmented apoptosis for cells at metaphase. in summary, we found sirt1 is able to localize in cytoplasm, and cytoplasm-localized sirt1 enhances apoptosis. |
| WOS关键词 | CELL-SURVIVAL ; CALORIE RESTRICTION ; TRANSCRIPTION FACTORS ; SIR2-ALPHA PROTEIN ; DNA-DAMAGE ; LIFE-SPAN ; P53 ; DEACETYLASE ; STRESS ; ACETYLATION |
| WOS研究方向 | Cell Biology ; Physiology |
| WOS类目 | Cell Biology ; Physiology |
| 语种 | 英语 |
| WOS记录号 | WOS:000249292000011 |
| 出版者 | WILEY-LISS |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2381380 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Zhai, Qiwei |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Grad Sch, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jin, Qihuang,Yan, Tingting,Ge, Xinjian,et al. Cytoplasm-localized sirt1 enhances apoptosis[J]. Journal of cellular physiology,2007,213(1):88-97. |
| APA | Jin, Qihuang,Yan, Tingting,Ge, Xinjian,Sun, Cheng,Shi, Xianglin,&Zhai, Qiwei.(2007).Cytoplasm-localized sirt1 enhances apoptosis.Journal of cellular physiology,213(1),88-97. |
| MLA | Jin, Qihuang,et al."Cytoplasm-localized sirt1 enhances apoptosis".Journal of cellular physiology 213.1(2007):88-97. |
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来源：中国科学院大学
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