Recent advances in mass spectrometry-based peptidome analysis
文献类型：期刊论文
| 作者 | Hu, Lianghai; Ye, Mingliang; Zou, Hanfa |
| 刊名 | expert review of proteomics
 |
| 出版日期 | 2009-08-01 |
| 卷号 | 6期号:4页码:433-447 |
| 关键词 | biomarker endogenous mass spectrometry multidimensional separation peptide peptidomics proteomics selective enrichment |
| ISSN号 | 1478-9450 |
| 产权排序 | 1;1 |
| 通讯作者 | 邹汉法 |
| 英文摘要 | the peptidome, which is the low-molecular-weight subset of the proteome, has attracted increasing attention in recent years. however, with the interference of high-abundance protein components in complex biological mixtures (e.g., serum), selective extraction of endogenous peptides is the first and most important step before analyzing the peptidome. a number of methods and technologies have now been developed for the selective enrichment, fractionation, quantitative analysis of the endogenous peptides and their application in the potential biomarker discovery. this review will cover the methods and technologies developed in recent years for the peptidome analysis on the selective extraction, multidimensional separation and quantitative analysis, as well as their application for clinical diagnosis and biomarker discovery. the future prospects of the peptidome are also discussed. |
| WOS标题词 | science & technology ; life sciences & biomedicine |
| 类目[WOS] | biochemical research methods |
| 研究领域[WOS] | biochemistry & molecular biology |
| 关键词[WOS] | 2-dimensional liquid-chromatography ; mesoporous silica particles ; cancer biomarker discovery ; molecular-weight proteins ; magnetic bead separation ; seldi-tof ms ; rp-rp-hplc ; human plasma ; endogenous peptides ; human serum |
| 收录类别 | SCI |
| 原文出处 | false |
| 语种 | 英语 |
| WOS记录号 | WOS:000270399200016 |
| 公开日期 | 2010-11-30 |
| 源URL | [http://159.226.238.44/handle/321008/101785]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | Chinese Acad Sci, Key Lab Separat Sci Analyt Chem, Natl Chromatog R&A Ctr, Dalian Inst Chem Phys, Dalian 116023, Peoples R China |
| 推荐引用方式 GB/T 7714 | Hu, Lianghai,Ye, Mingliang,Zou, Hanfa. Recent advances in mass spectrometry-based peptidome analysis[J]. expert review of proteomics,2009,6(4):433-447. |
| APA | Hu, Lianghai,Ye, Mingliang,&Zou, Hanfa.(2009).Recent advances in mass spectrometry-based peptidome analysis.expert review of proteomics,6(4),433-447. |
| MLA | Hu, Lianghai,et al."Recent advances in mass spectrometry-based peptidome analysis".expert review of proteomics 6.4(2009):433-447. |
入库方式： OAI收割
来源：大连化学物理研究所
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