Sirt1 improves insulin sensitivity under insulin-resistant conditions by repressing ptp1b
文献类型：期刊论文
| 作者 | Sun, Cheng; Zhang, Fang; Ge, Xinjian; Yan, Tingting; Chen, Xingmiao; Shi, Xianglin; Zhai, Qiwei |
| 刊名 | Cell metabolism
 |
| 出版日期 | 2007-10-01 |
| 卷号 | 6期号:4页码:307-319 |
| ISSN号 | 1550-4131 |
| DOI | 10.1016/j.cmet.2007.08.014 |
| 通讯作者 | Zhai, qiwei(qwzhai@sibs.ac.cn) |
| 英文摘要 | Insulin resistance is often characterized as the most critical factor contributing to the development of type 2 diabetes. sirt1 has been reported to be involved in the processes of glucose metabolism and insulin secretion. however, whether sirt1 is directly involved in insulin sensitivity is still largely unknown. here we show that sirt1 is down-regulated in insulin-resistant cells and tissues and that knockdown or inhibition of sirt1 induces insulin resistance. furthermore, increased expression of sirt1 improved insulin sensitivity, especially under insulin-resistant conditions. similarly, resveratrol, a sirt1 activator, enhanced insulin sensitivity in vitro in a sirt1-dependent manner and attenuated high-fat-diet-induced insulin resistance in vivo at a dose of 2.5 mg/kg/day. further studies demonstrated that the effect of sirt1 on insulin resistance is mediated by repressing ptp1b transcription at the chromatin level. taken together, the finding that sirt1 improves insulin sensitivity has implications toward resolving insulin resistance and type 2 diabetes. |
| WOS关键词 | PROTEIN-TYROSINE PHOSPHATASES ; PANCREATIC BETA-CELLS ; CALORIC RESTRICTION ; GLUCOSE ; RESVERATROL ; MICE ; KINASE ; FAMILY ; DEACETYLASES ; OBESITY |
| WOS研究方向 | Cell Biology ; Endocrinology & Metabolism |
| WOS类目 | Cell Biology ; Endocrinology & Metabolism |
| 语种 | 英语 |
| WOS记录号 | WOS:000249929000009 |
| 出版者 | CELL PRESS |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2381462 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Zhai, Qiwei |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Grad Sch, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Sun, Cheng,Zhang, Fang,Ge, Xinjian,et al. Sirt1 improves insulin sensitivity under insulin-resistant conditions by repressing ptp1b[J]. Cell metabolism,2007,6(4):307-319. |
| APA | Sun, Cheng.,Zhang, Fang.,Ge, Xinjian.,Yan, Tingting.,Chen, Xingmiao.,...&Zhai, Qiwei.(2007).Sirt1 improves insulin sensitivity under insulin-resistant conditions by repressing ptp1b.Cell metabolism,6(4),307-319. |
| MLA | Sun, Cheng,et al."Sirt1 improves insulin sensitivity under insulin-resistant conditions by repressing ptp1b".Cell metabolism 6.4(2007):307-319. |
入库方式： iSwitch采集
来源：中国科学院大学
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。