Roles of aurora kinases in mitosis and tumorigenesis
文献类型：期刊论文
| 作者 | Fu, Jingyan; Bian, Minglei; Jiang, Qing; Zhang, Chuanmao |
| 刊名 | Molecular cancer research
 |
| 出版日期 | 2007 |
| 卷号 | 5期号:1页码:1-10 |
| ISSN号 | 1541-7786 |
| DOI | 10.1158/1541-7786.mcr-06-0208 |
| 通讯作者 | Jiang, qing(jiangqing@pku.edu.cn) |
| 英文摘要 | Aurora kinases, which have been implicated in several vital events in mitosis, represent a protein kinase family highly conserved during evolution. the activity of aurora kinases is delicately regulated, mainly by phosphorylation and degradation. deregulation of aurora kinase activity can result in mitotic abnormality and genetic instability, leading to defects in centrosome function, spindle assembly, chromosome alignment, and cytokinesis. both the expression level and the kinase activity of aurora kinases are found to be up-regulated in many human cancers, indicating that these kinases might serve as useful targets for the development of anticancer drugs. this review focuses on recent progress on the roles of aurora kinases in mitosis and tumorigenesis. |
| WOS关键词 | CAENORHABDITIS-ELEGANS EMBRYOS ; CHROMOSOMAL PASSENGER PROTEIN ; SPINDLE ASSEMBLY CHECKPOINT ; HISTONE H3 PHOSPHORYLATION ; SUPPRESSES TUMOR-GROWTH ; SQUAMOUS-CELL CARCINOMA ; A KINASE ; MITOTIC SPINDLE ; B KINASE ; CLEAVAGE FURROW |
| WOS研究方向 | Oncology ; Cell Biology |
| WOS类目 | Oncology ; Cell Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000243845800001 |
| 出版者 | AMER ASSOC CANCER RESEARCH |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2381464 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Jiang, Qing |
| 作者单位 | 1.Peking Univ, Coll Life Sci, Minist Educ, Key Lab Cell Proliferat & Differentiat, Beijing 100871, Peoples R China 2.Peking Univ, Coll Life Sci, State Key Lab Biomembrane & Membrane Biotechnol, Beijing 100871, Peoples R China |
| 推荐引用方式 GB/T 7714 | Fu, Jingyan,Bian, Minglei,Jiang, Qing,et al. Roles of aurora kinases in mitosis and tumorigenesis[J]. Molecular cancer research,2007,5(1):1-10. |
| APA | Fu, Jingyan,Bian, Minglei,Jiang, Qing,&Zhang, Chuanmao.(2007).Roles of aurora kinases in mitosis and tumorigenesis.Molecular cancer research,5(1),1-10. |
| MLA | Fu, Jingyan,et al."Roles of aurora kinases in mitosis and tumorigenesis".Molecular cancer research 5.1(2007):1-10. |
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来源：中国科学院大学
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