Differential expression and functional constraint of prl-2 in hibernating bat
文献类型：期刊论文
| 作者 | Yuan, Lihong; Chen, Jinping; Lin, Benfu; Zhang, Junpeng; Zhang, Shuyi |
| 刊名 | Comparative biochemistry and physiology b-biochemistry & molecular biology
 |
| 出版日期 | 2007-12-01 |
| 卷号 | 148期号:4页码:375-381 |
| 关键词 | Differential expression Functional constraint Hibernaing bat Prl-2 |
| ISSN号 | 1096-4959 |
| DOI | 10.1016/j.cbpb.2007.07.005 |
| 通讯作者 | Zhang, shuyi(syzhang@bio.ecnu.edu.cn) |
| 英文摘要 | Circannual hibernation is a biological adaptation to periods of cold and food shortage and the role of the brain in its control is poorly understood. an ssh library of hibernating bat brains (rhinolophus ferrumequinum) was constructed in order to explore the molecular mechanism of hibernation. an up-regulated gene, prl-2, was obtained from hibernating bat brains. prl-2 is a member of ptp family and has an important function in controlling cell growth. alignment of sequences showed that prl-2 is highly conserved among species, including two species of hibernating bats (r. ferrumequinum and myotis ricketti). moreover, maximum likelihood analysis suggested that it may experience strong selection pressure leading to functional constraint in evolution, which indicated the significance of prl-2 in normal bio-function. rq-pcr was performed and statistical analysis suggested that prl-2 exhibited distinct differential expression patterns in different organs during hibernation. in heart, fat and brain tissue of hibernating bats, the transcriptional level of prl-2 increased almost 170%, 35% and 12% respectively. however, in muscle it decreased nearly 70%. the change of mrna level of prl-2 in heart tissue of hibernating bats was significantly higher than that in heart tissue of active controls (p=0.043). however, the regulation mechanism of differential expression of prl-2 and the signal pathway involved are still unknown. (c) 2007 elsevier inc. all rights reserved. |
| WOS关键词 | PROTEIN-TYROSINE-PHOSPHATASE ; CELL-CYCLE PROGRESSION ; AMINO-ACID SITES ; MAMMALIAN HIBERNATION ; TUMOR-SUPPRESSOR ; UP-REGULATION ; GROUND SQUIRRELS ; GENE-EXPRESSION ; BRAIN ; PTEN |
| WOS研究方向 | Biochemistry & Molecular Biology ; Zoology |
| WOS类目 | Biochemistry & Molecular Biology ; Zoology |
| 语种 | 英语 |
| WOS记录号 | WOS:000251481700003 |
| 出版者 | ELSEVIER SCIENCE INC |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2381763 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Zhang, Shuyi |
| 作者单位 | 1.E China Normal Univ, Sch Life Sci, Shanghai 200062, Peoples R China 2.Chinese Acad Sci, Inst Zool, Beijing 100080, Peoples R China 3.Chinese Acad Sci, Grad Univ, Beijing 100080, Peoples R China 4.Inst Entomol, Guangzhou 510260, Peoples R China 5.Chinese Acad Sci, Inst Biomed Hlth, Guangzhou 510663, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yuan, Lihong,Chen, Jinping,Lin, Benfu,et al. Differential expression and functional constraint of prl-2 in hibernating bat[J]. Comparative biochemistry and physiology b-biochemistry & molecular biology,2007,148(4):375-381. |
| APA | Yuan, Lihong,Chen, Jinping,Lin, Benfu,Zhang, Junpeng,&Zhang, Shuyi.(2007).Differential expression and functional constraint of prl-2 in hibernating bat.Comparative biochemistry and physiology b-biochemistry & molecular biology,148(4),375-381. |
| MLA | Yuan, Lihong,et al."Differential expression and functional constraint of prl-2 in hibernating bat".Comparative biochemistry and physiology b-biochemistry & molecular biology 148.4(2007):375-381. |
入库方式： iSwitch采集
来源：中国科学院大学
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。