E2f6 negatively regulates ultraviolet-induced apoptosis via modulation of brca1
文献类型：期刊论文
| 作者 | Yang, W. -W.; Wang, Z. -H.; Zhu, Y.; Yang, H. -T. |
| 刊名 | Cell death and differentiation
 |
| 出版日期 | 2007-04-01 |
| 卷号 | 14期号:4页码:807-817 |
| 关键词 | Dna damage Transcription Cleavage Nuclear foci Apoptosis |
| ISSN号 | 1350-9047 |
| DOI | 10.1038/sj.cdd.4402062 |
| 通讯作者 | Yang, h. -t.(htyang@sibs.ac.cn) |
| 英文摘要 | E2f6 is believed to repress e2f-responsive genes and therefore plays an important role in cell-cycle regulation. however, the role of e2f6 in the control of apoptosis remains unknown. we show here that the expression of e2f6 was downregulated with a concurrent increase in brca1 mrna and cleaved protein during ultraviolet (uv)-induced apoptosis in human embryonic kidney 293 cells. moreover, e2f6 overexpression distinctly inhibited uv-induced apoptosis as well as uv-induced increases in brca1 expression and cleavage, accompanied with increases of the full-length brca1 and brca1 nuclear foci. in contrast, knockdown of e2f6 by small interfering rna had opposite effects. furthermore, these effects of e2f6 on brca1 depended upon the association of e2f6 with brca1 via its c-terminus in a uv-triggered manner and upon the transcriptional repression by e2f6 on the brca1 promoter. these findings provide the first demonstration of the important role for e2f6 in the control of apoptosis via targeting of brca1. |
| WOS关键词 | DNA-DAMAGE RESPONSE ; INDUCED CELL-DEATH ; FAMILY-MEMBER ; CANCER-CELLS ; REPAIR ; INDUCTION ; RADIATION ; PHOSPHORYLATION ; IDENTIFICATION ; PROLIFERATION |
| WOS研究方向 | Biochemistry & Molecular Biology ; Cell Biology |
| WOS类目 | Biochemistry & Molecular Biology ; Cell Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000245102900017 |
| 出版者 | NATURE PUBLISHING GROUP |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2381956 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Yang, H. -T. |
| 作者单位 | 1.Chinese Acad Sci, Lab Mol Cardiol, Inst Hlth Sci, Shanghai Inst Biol Sci, Shanghai 200025, Peoples R China 2.Shanghai Jiao Tong Univ, Sch Med, Shanghai 200030, Peoples R China 3.CAS, Grad Sch, Shanghai, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, W. -W.,Wang, Z. -H.,Zhu, Y.,et al. E2f6 negatively regulates ultraviolet-induced apoptosis via modulation of brca1[J]. Cell death and differentiation,2007,14(4):807-817. |
| APA | Yang, W. -W.,Wang, Z. -H.,Zhu, Y.,&Yang, H. -T..(2007).E2f6 negatively regulates ultraviolet-induced apoptosis via modulation of brca1.Cell death and differentiation,14(4),807-817. |
| MLA | Yang, W. -W.,et al."E2f6 negatively regulates ultraviolet-induced apoptosis via modulation of brca1".Cell death and differentiation 14.4(2007):807-817. |
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来源：中国科学院大学
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