Enantioseparation of rivastigmine by high performance liquid chromatography using vancomycin chiral stationary phase
文献类型：期刊论文
| 作者 | Xu Zhe; Zhou Ning; Xu Xu; Xu Xing-Xiang |
| 刊名 | Chinese journal of analytical chemistry
 |
| 出版日期 | 2007-07-01 |
| 卷号 | 35期号:7页码:1043-1046 |
| 关键词 | High performance liquid chromatography Enantioseparation Vancomycin Chiral stationary Phase Rivastigmine |
| ISSN号 | 0253-3820 |
| 通讯作者 | Xu xu(xuxu@mail.sioc.ac.cn) |
| 英文摘要 | Direct enantioseparation of rivastigmine was achieved by high performance liquid chromatography using a vancomycin bound chiral stationary phase. the effects of the content and ratio of acetic acid/triethylamine in the mobile phase, acid additive, column temperature and flow rate of mobile phase on the enantioseparation of rivastigmine were studied. by using the chirobiotic v column (250 mm x 4.6 mm i. d., 5 mu m), and methanol: acetic acid: triethylamine (100: 0. 02: 0. 01, v/v) as mobile phase, flow rate of 0. 5 ml/min, detection wavelength of 274 nm, enantioseparation of rivastigmine was achieved. the relationship between ln alpha and 1/t was investigated in the range of 5 - 30 degrees t. the linear equation is ln alpha = delta delta h degrees/rt + aas degrees/r. |
| WOS关键词 | TANDEM MASS-SPECTROMETRY ; CAPILLARY-ELECTROPHORESIS ; MACROCYCLIC ANTIBIOTICS ; SEPARATION ; SELECTORS |
| WOS研究方向 | Chemistry |
| WOS类目 | Chemistry, Analytical |
| 语种 | 英语 |
| WOS记录号 | WOS:000249446200026 |
| 出版者 | SCIENCE CHINA PRESS |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2382185 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Xu Xu |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Organ Chem, Shanghai 200032, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xu Zhe,Zhou Ning,Xu Xu,et al. Enantioseparation of rivastigmine by high performance liquid chromatography using vancomycin chiral stationary phase[J]. Chinese journal of analytical chemistry,2007,35(7):1043-1046. |
| APA | Xu Zhe,Zhou Ning,Xu Xu,&Xu Xing-Xiang.(2007).Enantioseparation of rivastigmine by high performance liquid chromatography using vancomycin chiral stationary phase.Chinese journal of analytical chemistry,35(7),1043-1046. |
| MLA | Xu Zhe,et al."Enantioseparation of rivastigmine by high performance liquid chromatography using vancomycin chiral stationary phase".Chinese journal of analytical chemistry 35.7(2007):1043-1046. |
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来源：中国科学院大学
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