Ecs: an automatic enzyme classifier based on functional domain composition
文献类型：期刊论文
| 作者 | Lu, Lingyi; Qian, Ziliang; Cai, Yu-Dong; Li, Yixue |
| 刊名 | Computational biology and chemistry
 |
| 出版日期 | 2007-06-01 |
| 卷号 | 31期号:3页码:226-232 |
| 关键词 | Enzyme Classification Functional domain composition Support vector machine |
| ISSN号 | 1476-9271 |
| DOI | 10.1016/j.compbiolchem.2007.03.008 |
| 通讯作者 | Cai, yu-dong(cyd@picb.ac.cn) |
| 英文摘要 | Classification for enzymes is a prerequisite for understanding their function. here, an automatic enzyme identifier based on support vector machine (svm) with feature vectors from protein functional domain composition was built to identify enzymes and further a classifier to classify enzymes into six different classes: oxidoreductase, transferase, hydrolase, lyase, isomerase and ligase. jackknife cross-validation test was adopted to evaluate the performance of our classifier. the 86.03% success rate achieved for enzyme/non-enzyme identification and 91.32% for enzyme classification, which is much better than that of the blast and psi-blast based method, also outperforms several existed works. the results indicate that protein functional domain composition is able to capture the major features which facilitate the identification/classification of proteins, thus demonstrating that our predictor could be a more effective and promising high-throughput method in enzyme research. moreover, a web-based software enzyme classification system (ecs) for identification as well as classification of enzymes can be accessed at: http://pcal.biosino.org/. (c) 2007 elsevier ltd. all rights reserved. |
| WOS关键词 | SUPPORT VECTOR MACHINES ; PROTEIN ; SEQUENCE |
| WOS研究方向 | Life Sciences & Biomedicine - Other Topics ; Computer Science |
| WOS类目 | Biology ; Computer Science, Interdisciplinary Applications |
| 语种 | 英语 |
| WOS记录号 | WOS:000247289900010 |
| 出版者 | ELSEVIER SCI LTD |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2382220 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Cai, Yu-Dong |
| 作者单位 | 1.Univ Manchester, Inst Sci & Technol, Dept Math, Manchester M60 1QD, Lancs, England 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Biol Sci, CAS MPG Partner Inst Computat Biol, Beijing 100039, Peoples R China 4.Acad Sinica, Shanghai Inst Biol Sci, Bioinformat Ctr, Key Lab Mol Syst Biol, Shanghai 200031, Peoples R China 5.Shanghai Ctr Bioinformat Technol, Shanghai 200235, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lu, Lingyi,Qian, Ziliang,Cai, Yu-Dong,et al. Ecs: an automatic enzyme classifier based on functional domain composition[J]. Computational biology and chemistry,2007,31(3):226-232. |
| APA | Lu, Lingyi,Qian, Ziliang,Cai, Yu-Dong,&Li, Yixue.(2007).Ecs: an automatic enzyme classifier based on functional domain composition.Computational biology and chemistry,31(3),226-232. |
| MLA | Lu, Lingyi,et al."Ecs: an automatic enzyme classifier based on functional domain composition".Computational biology and chemistry 31.3(2007):226-232. |
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来源：中国科学院大学
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