Functional analysis of schistosomes ef-hand domain-containing tegument proteins
文献类型：期刊论文
| 作者 | Yu FuDong; Kang Bin; Li YuanYuan; Li YiXue |
| 刊名 | Chinese science bulletin
 |
| 出版日期 | 2007-08-01 |
| 卷号 | 52期号:15页码:2100-2107 |
| 关键词 | Chistosomes Host-parasite interaction Tegument proteins Ef-hand domain Bioinformatics |
| ISSN号 | 1001-6538 |
| DOI | 10.1007/s11434-007-0312-z |
| 通讯作者 | Li yixue(yxli@sibs.ac.cn) |
| 英文摘要 | Schistosomes cause schistosomiasis disease which severely threatens human health. little is known about the functions of ef-hand domain containing schistosomes tegument proteins other than as antigens. more possible functions of these tegument proteins were investigated with in silico analyses including protein-protein functional interaction, site-specific variation and glycosylation modification. the analysis results suggested that schistosomes could actively modulate host immune responses for its own favor through functional interactions with host proteins with immunomodulatory function, and passively regulate host immune responses through sequence variation under positive selection and glycosylating the recognition sites of host immune attack. in addition, the analysis of the c-terminal domain of these tegument proteins indicated that they could assist schistosomes in escaping host immune attacks through inhibiting chemotaxis and non-complement fixing antibody (igg4) responses. in summary, our results suggested that these tegument antigen proteins could assist schistosomes in escaping and modulating host immune responses for self-protection during the process of host-parasite interaction. |
| WOS关键词 | HUMAN IGE RESPONSE ; COMPLEX ; ANTIGENS ; BINDING ; CALMODULIN ; JAPONICUM ; MANSONI ; IDENTIFICATION ; RESOLUTION ; EXPRESSION |
| WOS研究方向 | Science & Technology - Other Topics |
| WOS类目 | Multidisciplinary Sciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000248663700013 |
| 出版者 | SCIENCE PRESS |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2382299 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Li YiXue |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Biol Sci, Key Lab Syst Biol, Bioinformat Ctr, Shanghai 200031, Peoples R China 2.Chinese Acad Sci, Grad Univ, Shanghai 200031, Peoples R China 3.Shanghai Ctr Bioinformat Technol, Shanghai 200235, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yu FuDong,Kang Bin,Li YuanYuan,et al. Functional analysis of schistosomes ef-hand domain-containing tegument proteins[J]. Chinese science bulletin,2007,52(15):2100-2107. |
| APA | Yu FuDong,Kang Bin,Li YuanYuan,&Li YiXue.(2007).Functional analysis of schistosomes ef-hand domain-containing tegument proteins.Chinese science bulletin,52(15),2100-2107. |
| MLA | Yu FuDong,et al."Functional analysis of schistosomes ef-hand domain-containing tegument proteins".Chinese science bulletin 52.15(2007):2100-2107. |
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来源：中国科学院大学
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