Fludarabine reduces survivability of hepg2 cells through vegf under hypoxia
文献类型：期刊论文
| 作者 | Xue, Jing; Bi, Xinsheng; Wu, Guohao; Meng, Dan; Fang, Jing |
| 刊名 | Archives of biochemistry and biophysics
 |
| 出版日期 | 2007-12-01 |
| 卷号 | 468期号:1页码:100-106 |
| ISSN号 | 0003-9861 |
| 关键词 | Fludarabine Vascular endothelial growth factor Hypoxia-inducible factor 1 Tumor Survivability |
| DOI | 10.1016/j.abb.2007.09.013 |
| 通讯作者 | Fang, jing(jfang@sibs.ac.cn) |
| 英文摘要 | Fludarabine is the major drug against chronic lymphoblastic leukemia. however, the effects of fludarabine on solid tumors remain unclear. we reported previously that fludarabine inhibited expression of hypoxia-inducible factor lot (hif-1 alpha) and vascular endothelial growth factor (vegf) in human ovarian cancer cells. the present study aims to investigate, (1) the mechanisms that fludarabine inhibits expression of hif-1 alpha and (2) the effects of fludarabine on tumor cells survival under hypoxia. human hepatoma hepg2 cells were tested. we found that fludarabine reduced hif-1 alpha stability through prolyl hydroxylation. fludarabine suppressed hypoxia-induced expression of vegf and its receptor kdr. it inhibited vegf-induced activation of akt and erk signaling and reduced hypoxia-enhanced hepg2 cell survivability. hepg2 cells were much more sensitive to fludarabine treatment under hypoxia than under nomoxia. these results suggest that fludarabine reduces survivability of hepg2 cells via vegf signaling under hypoxia. (c) 2007 elsevier inc. all rights reserved. |
| WOS关键词 | ENDOTHELIAL GROWTH-FACTOR ; FOLLICULAR THYROID-CANCER ; INDUCED APOPTOSIS ; PROSTATE-CANCER ; FACTOR RECEPTOR ; FACTOR 1-ALPHA ; HIF-ALPHA ; IN-VITRO ; EXPRESSION ; KDR |
| WOS研究方向 | Biochemistry & Molecular Biology ; Biophysics |
| WOS类目 | Biochemistry & Molecular Biology ; Biophysics |
| 语种 | 英语 |
| 出版者 | ELSEVIER SCIENCE INC |
| WOS记录号 | WOS:000251352500011 |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2382338 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Fang, Jing |
| 作者单位 | 1.Chinese Acad Sci, Grad Sch, Shanghai Inst Biol Sci, Inst Nutr Sci, Shanghai 200031, Peoples R China 2.Gannan Med Univ, Analyt Lab, Ganzhou, Peoples R China 3.Fudan Univ, Sch Med, Dept Surg, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xue, Jing,Bi, Xinsheng,Wu, Guohao,et al. Fludarabine reduces survivability of hepg2 cells through vegf under hypoxia[J]. Archives of biochemistry and biophysics,2007,468(1):100-106. |
| APA | Xue, Jing,Bi, Xinsheng,Wu, Guohao,Meng, Dan,&Fang, Jing.(2007).Fludarabine reduces survivability of hepg2 cells through vegf under hypoxia.Archives of biochemistry and biophysics,468(1),100-106. |
| MLA | Xue, Jing,et al."Fludarabine reduces survivability of hepg2 cells through vegf under hypoxia".Archives of biochemistry and biophysics 468.1(2007):100-106. |
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来源：中国科学院大学
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