Injectable hydrogels of poly(epsilon-caprolactone-co-glycolide)-poly(ethylene glycol)-poly(epsilon-caprolactone-co-glycolide) triblock copolymer aqueous solutions
文献类型：期刊论文
| 作者 | Jiang, Zhiqiang; You, Yujing; Deng, Xianmo; Hao, Jianyuan |
| 刊名 | Polymer
 |
| 出版日期 | 2007-07-27 |
| 卷号 | 48期号:16页码:4786-4792 |
| 关键词 | Hydrogels Micelles Phase transition |
| ISSN号 | 0032-3861 |
| DOI | 10.1016/j.polymer.2007.06.003 |
| 通讯作者 | Hao, jianyuan(j.hao@cioc.ac.cn) |
| 英文摘要 | Thermogelling triblock copolymers of poly(e-caprolactone-co-glycolide)-poly(ethylene glycol)-poly(r-caprolactone-co-glycolide) [p(cl-ga)-peg-p(cl-ga)1 were successfully prepared by control of the hydrophilicity/hydrophobicity balance and chemical compositions of the copolymers. the aqueous solutions of the copolymers underwent sol-gel transition as the temperature was increased from 20 to 60 degrees c. the amphiphilic copolymer formed micelles in water and a gel was formed by aggregation of micelles. the structure parameters played a critical role in determining sol-gel transition behavior. either increasing [ga]/[cl] ratio or decreasing p(cl-ga) block length could induce the increase of the lower sol-get transition temperature. glycolide (ga) was incorporated into the polymer chain to increase the polymer degradation rate. sustained release of rifampicin for approximately 32 days was obtained from the gel. it is believed to have potential applications in drug delivery and tissue engineering. (c) 2007 elsevier ltd. all rights reserved. |
| WOS关键词 | PLGA-PEG-PLGA ; BIODEGRADABLE BLOCK-COPOLYMERS ; IN-VITRO ; DELIVERY ; ASSOCIATION ; DEGRADATION ; TEMPERATURE ; MICROGELS ; PROTEINS ; BEHAVIOR |
| WOS研究方向 | Polymer Science |
| WOS类目 | Polymer Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000248860400019 |
| 出版者 | ELSEVIER SCI LTD |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2382346 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Hao, Jianyuan |
| 作者单位 | 1.Chinese Acad Sci, Chengdu Inst Organ Chem, Chengdu 610041, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jiang, Zhiqiang,You, Yujing,Deng, Xianmo,et al. Injectable hydrogels of poly(epsilon-caprolactone-co-glycolide)-poly(ethylene glycol)-poly(epsilon-caprolactone-co-glycolide) triblock copolymer aqueous solutions[J]. Polymer,2007,48(16):4786-4792. |
| APA | Jiang, Zhiqiang,You, Yujing,Deng, Xianmo,&Hao, Jianyuan.(2007).Injectable hydrogels of poly(epsilon-caprolactone-co-glycolide)-poly(ethylene glycol)-poly(epsilon-caprolactone-co-glycolide) triblock copolymer aqueous solutions.Polymer,48(16),4786-4792. |
| MLA | Jiang, Zhiqiang,et al."Injectable hydrogels of poly(epsilon-caprolactone-co-glycolide)-poly(ethylene glycol)-poly(epsilon-caprolactone-co-glycolide) triblock copolymer aqueous solutions".Polymer 48.16(2007):4786-4792. |
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来源：中国科学院大学
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