Prediction of subcellular protein localization based on functional domain composition
文献类型：期刊论文
| 作者 | Jia, Peilin; Qian, Ziliang; Zeng, ZhenBin; Cai, Yudong; Li, Yixue |
| 刊名 | Biochemical and biophysical research communications
 |
| 出版日期 | 2007-06-01 |
| 卷号 | 357期号:2页码:366-370 |
| 关键词 | Protein subcellular localization Pfam Nearest neighbor algorithm |
| ISSN号 | 0006-291X |
| DOI | 10.1016/j.bbrc.2007.03.139 |
| 通讯作者 | Li, yixue(yxli@scbit.org) |
| 英文摘要 | Assigning subcellular localization (sl) to proteins is one of the major tasks of functional proteomics. despite the impressive technical advances of the past decades, it is still time-consuming and laborious to experimentally determine sl on a high throughput scale. thus, computational predictions are the preferred method for large-scale assignment of protein sl, and if appropriate, followed up by experimental studies. in this report, using a machine learning approach, the nearest neighbor algorithm (nna), we developed a prediction system for protein sl in which we incorporated a protein functional domain profile. the overall accuracy achieved by this system is 93.96%. furthermore, comparisons with other methods have been conducted to demonstrate the validity and efficiency of our prediction system. we also provide an implementation of our subcellular location prediction system (slps), which is available at http://pcal.biosino.org. (c) 2007 elsevier inc. all rights reserved. |
| WOS关键词 | SUPPORT VECTOR MACHINES ; NEURAL-NETWORKS ; BUDDING YEAST ; LOCATIONS |
| WOS研究方向 | Biochemistry & Molecular Biology ; Biophysics |
| WOS类目 | Biochemistry & Molecular Biology ; Biophysics |
| 语种 | 英语 |
| WOS记录号 | WOS:000246253700007 |
| 出版者 | ACADEMIC PRESS INC ELSEVIER SCIENCE |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2382419 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Li, Yixue |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Biol Sci, Key Lab Syst Biol, Bioinformat Ctr, Shanghai 200031, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Biol Sci, MPG Partner Inst Computat Biol, Shanghai, Peoples R China 4.Univ Manchester, Dept Math, Manchester M60 1QD, Lancs, England 5.Shanghai Ctr Bioinformat Technol, Shanghai 200235, Peoples R China 6.Shanghai Jiao Tong Univ, Life Sci Sch, Shanghai 200030, Peoples R China 7.E China Normal Univ, Software Engn Inst, Shanghai 200062, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jia, Peilin,Qian, Ziliang,Zeng, ZhenBin,et al. Prediction of subcellular protein localization based on functional domain composition[J]. Biochemical and biophysical research communications,2007,357(2):366-370. |
| APA | Jia, Peilin,Qian, Ziliang,Zeng, ZhenBin,Cai, Yudong,&Li, Yixue.(2007).Prediction of subcellular protein localization based on functional domain composition.Biochemical and biophysical research communications,357(2),366-370. |
| MLA | Jia, Peilin,et al."Prediction of subcellular protein localization based on functional domain composition".Biochemical and biophysical research communications 357.2(2007):366-370. |
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来源：中国科学院大学
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