A 4.3 kb smad7 promoter is able to specify gene expression during mouse development
文献类型：期刊论文
| 作者 | Liu, Xubao; Chen, Qian; Kuang, Chenzhong; Zhang, Meiyu; Ruan, Yiwen; Xu, Zao C.; Wang, Zhenzhen; Chen, Yan |
| 刊名 | Biochimica et biophysica acta-gene structure and expression
 |
| 出版日期 | 2007-02-01 |
| 卷号 | 1769期号:2页码:149-152 |
| 关键词 | Tgf-beta Activin Smad7 Heart Aorta Cochlea Nasolacrimal duct Development Transgenic |
| ISSN号 | 0167-4781 |
| DOI | 10.1016/j.bbaexp.2007.01.001 |
| 通讯作者 | Chen, yan(ychen3@iupui.edu) |
| 英文摘要 | Members of transforming growth factor-beta (tgf-beta) superfamily play important roles in diverse biological functions including early development. these extracellular factors exert their effects by interacting with membrane receptors followed by signal transduction by a group of smad proteins. smad7 is an inhibitory smad protein that specifically antagonizes tgf-beta and activin signaling. to characterize the developmental role of smad7, a transgenic mouse model was generated using a 4.3 kb mouse smad7 promoter driving beta-galactosidase expression. in these mice, the smad7 promoter defined a restrictive expression pattern of beta-galactosidase in a tightly regulated temporal and spatial manner. the beta-galactosidase gene was transiently expressed in the cardiovascular structures including heart cushion tissues and the endothelium of major arteries at e11.5 to e12.5. through e12.5 to e17.5, beta-galactosidase expression was prominently detected in the epithelium of developing cochlea and nasolacrimal duct. in addition, it was temporally expressed in trigeminal ganglion, the skeletal muscles surrounding major joints, primordium of the jaws, as well as genital tubercle. these studies indicated that the 4.3 kb smad7 promoter contains sufficient regulatory elements to define controlled gene expression during mouse development. (c) 2007 elsevier b.v. all rights reserved. |
| WOS关键词 | BETA ; ANTAGONIST ; RECEPTOR |
| WOS研究方向 | Biochemistry & Molecular Biology ; Biophysics |
| WOS类目 | Biochemistry & Molecular Biology ; Biophysics |
| 语种 | 英语 |
| WOS记录号 | WOS:000245491000008 |
| 出版者 | ELSEVIER SCIENCE BV |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2382532 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Chen, Yan |
| 作者单位 | 1.Indiana Univ, Sch Med, Dept Med & Mol Genet, Indianapolis, IN 46202 USA 2.Indiana Univ, Sch Med, Walther Oncol Ctr, Indianapolis, IN 46202 USA 3.Indiana Univ, Sch Med, Dept Anat & Cell Biol, Indianapolis, IN 46202 USA 4.Chinese Acad Sci, Grad Sch, Shanghai Inst Biol Sci, Inst Nutr Sci, Shanghai 200031, Peoples R China 5.Sichuan Univ, W China Hosp, Dept Gen Surg, Chengdu 610041, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Xubao,Chen, Qian,Kuang, Chenzhong,et al. A 4.3 kb smad7 promoter is able to specify gene expression during mouse development[J]. Biochimica et biophysica acta-gene structure and expression,2007,1769(2):149-152. |
| APA | Liu, Xubao.,Chen, Qian.,Kuang, Chenzhong.,Zhang, Meiyu.,Ruan, Yiwen.,...&Chen, Yan.(2007).A 4.3 kb smad7 promoter is able to specify gene expression during mouse development.Biochimica et biophysica acta-gene structure and expression,1769(2),149-152. |
| MLA | Liu, Xubao,et al."A 4.3 kb smad7 promoter is able to specify gene expression during mouse development".Biochimica et biophysica acta-gene structure and expression 1769.2(2007):149-152. |
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来源：中国科学院大学
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