Dark rearing alters the short-term synaptic plasticity in visual cortex
文献类型：期刊论文
| 作者 | Tang, Ai-Hui; Chai, Zhen; Wang, Shi-Qiang |
| 刊名 | Neuroscience letters
 |
| 出版日期 | 2007-07-05 |
| 卷号 | 422期号:1页码:49-53 |
| 关键词 | Short-term depression Dark-rear Visual cortex Experience Steady-state depression Paired-pulse depression Excitation/inhibition balance |
| ISSN号 | 0304-3940 |
| DOI | 10.1016/j.neutet.2007.05.053 |
| 通讯作者 | Wang, shi-qiang(wsq@pku.edu.cn) |
| 英文摘要 | The strength of all chemical synapses can be rapidly up-or down-regulated by their recent activities to reshape the postsynaptic signal through a mechanism of short-term facilitation or depression. it is also true that sensory experience is essential for maturation of cortical circuits and function. we studied the effect of sensory experience on the short-term plasticity in brain slices of rat visual cortex. repetitive stimulation was applied in layer ii/iii and the response of pyramidal neuron in layer v was examined by whole-cell recording. we deprived the visual experience of rats by rearing the animals in dark environment. we found that dark rearing (dr) had no effects on paired-pulse interactions of either excitatory postsynaptic currents (epscs) or inhibitory postsynaptic currents (ipscs). however, dr increased the level of ipscs steady-state depression at stimulation frequency of 20 hz or more. this result, together with the finding that dr reduced the excitability of neural circuit in visual cortex, suggested a compensatory mechanism, which may be important in enhancing the network excitability at a time when synapses are immature. (c) 2007 elsevier ireland ltd. all rights reserved. |
| WOS关键词 | NEUROTRANSMITTER RELEASE ; PYRAMIDAL NEURONS ; REARED RATS ; DEPRESSION ; SYNAPSES ; GABA ; TRANSMISSION ; DEPRIVATION ; INHIBITION ; NEOCORTEX |
| WOS研究方向 | Neurosciences & Neurology |
| WOS类目 | Neurosciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000248875800010 |
| 出版者 | ELSEVIER IRELAND LTD |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2382542 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Wang, Shi-Qiang |
| 作者单位 | Peking Univ, Coll Life Sci, State Key Lab Biomembrane & Membrane Biotechnol, Beijing 100871, Peoples R China |
| 推荐引用方式 GB/T 7714 | Tang, Ai-Hui,Chai, Zhen,Wang, Shi-Qiang. Dark rearing alters the short-term synaptic plasticity in visual cortex[J]. Neuroscience letters,2007,422(1):49-53. |
| APA | Tang, Ai-Hui,Chai, Zhen,&Wang, Shi-Qiang.(2007).Dark rearing alters the short-term synaptic plasticity in visual cortex.Neuroscience letters,422(1),49-53. |
| MLA | Tang, Ai-Hui,et al."Dark rearing alters the short-term synaptic plasticity in visual cortex".Neuroscience letters 422.1(2007):49-53. |
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来源：中国科学院大学
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