Genome sequencing and comparative analysis of saccharomyces cerevisiae strain yjm789
文献类型：期刊论文
| 作者 | Wei, Wu; McCusker, John H.; Hyman, Richard W.; Jones, Ted; Ning, Ye; Cao, Zhiwei; Gu, Zhenglong; Bruno, Dan; Miranda, Molly; Nguyen, Michelle |
| 刊名 | Proceedings of the national academy of sciences of the united states of america
 |
| 出版日期 | 2007-07-31 |
| 卷号 | 104期号:31页码:12825-12830 |
| 关键词 | Comparative genomics Genome architecture Introgression Lateral gene transfer |
| ISSN号 | 0027-8424 |
| DOI | 10.1073/pnas.0701291104 |
| 通讯作者 | Steinmetz, lars m.(larsms@embl.de) |
| 英文摘要 | We sequenced the genome of saccharomyces cerevisiae strain yjm789, which was derived from a yeast isolated from the lung of an aids patient with pneumonia. the strain is used for studies of fungal infections and quantitative genetics because of its extensive phenotypic differences to the laboratory reference strain, including growth at high temperature and deadly virulence in mouse models. here we show that the approximate to 12-mb genome of yjm789 contains approximate to 60,000 snps and approximate to 6,000 indels with respect to the reference s288c genome, leading to protein polymorphisms with a few known cases of phenotypic changes. several orfs are found to be unique to yjm789, some of which might have been acquired through horizontal transfer. localized regions of high polymorphism density are scattered over the genome, in some cases spanning multiple orfs and in others concentrated within single genes. the sequence of yjm789 contains clues to pathogenicity and spurs the development of more powerful approaches to dissecting the genetic basis of complex hereditary traits. |
| WOS关键词 | QUANTITATIVE TRAIT LOCUS ; HORIZONTAL-GENE-TRANSFER ; DUP240 MULTIGENE FAMILY ; NUCLEOTIDE RESOLUTION ; EVOLUTIONARY RATES ; YEAST ; IDENTIFICATION ; DIVERSITY ; SURVIVAL ; MUTATION |
| WOS研究方向 | Science & Technology - Other Topics |
| WOS类目 | Multidisciplinary Sciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000248603900043 |
| 出版者 | NATL ACAD SCIENCES |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2382544 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Steinmetz, Lars M. |
| 作者单位 | 1.Chinese Acad Sci, Grad Sch, Shanghai Inst Biolsci, Key Lab Syst Biol,Bioinformat Ctr, Shanghai 200031, Peoples R China 2.Shanghai Ctr Bioinformat Technol, Shanghai 200235, Peoples R China 3.Duke Univ, Med Ctr, Dept Mol Genet & Microbiol, Durham, NC 27710 USA 4.Stanford Univ, Dept Biochem, Stanford Genome Technol Ctr, Palo Alto, CA 94304 USA 5.Cornell Univ, Div Nutr Sci, Ithaca, NY 14853 USA 6.European Mol Biol Lab, D-69117 Heidelberg, Germany |
| 推荐引用方式 GB/T 7714 | Wei, Wu,McCusker, John H.,Hyman, Richard W.,et al. Genome sequencing and comparative analysis of saccharomyces cerevisiae strain yjm789[J]. Proceedings of the national academy of sciences of the united states of america,2007,104(31):12825-12830. |
| APA | Wei, Wu.,McCusker, John H..,Hyman, Richard W..,Jones, Ted.,Ning, Ye.,...&Steinmetz, Lars M..(2007).Genome sequencing and comparative analysis of saccharomyces cerevisiae strain yjm789.Proceedings of the national academy of sciences of the united states of america,104(31),12825-12830. |
| MLA | Wei, Wu,et al."Genome sequencing and comparative analysis of saccharomyces cerevisiae strain yjm789".Proceedings of the national academy of sciences of the united states of america 104.31(2007):12825-12830. |
入库方式： iSwitch采集
来源：中国科学院大学
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。