Rna interference as a novel and powerful tool in immunopharmacological research
文献类型：期刊论文
| 作者 | Kong, Yan; Ruan, Lingfei; Ma, Lili; Cui, Youhong; Wang, Ji Ming; Le, Yingying |
| 刊名 | International immunopharmacology
 |
| 出版日期 | 2007-04-01 |
| 卷号 | 7期号:4页码:417-426 |
| 关键词 | Rna interference Sirna Therapeutics Immune system |
| ISSN号 | 1567-5769 |
| DOI | 10.1016/j.intimp.2006.12.011 |
| 通讯作者 | Le, yingying(yyle@sibs.ac.cn) |
| 英文摘要 | Rna interference (rnai), as an evolutionarily conserved mechanism for silencing gene expression, is realized through the actions of both small interference rna (sirna) and microrna. since its discovery, sirna has been rapidly deployed not only for the elucidation of gene function, but also for identification of drug targets and as a powerful therapeutic approach for a variety of diseases. in this review, we briefly introduce the mechanisms of rnai, methods of sirna design and delivery, and summarized recent researches on the therapeutic potential of rnai for immune diseases. (c) 2007 elsevier b.v. all rights reserved. |
| WOS关键词 | DOUBLE-STRANDED-RNA ; FORMYLPEPTIDE RECEPTOR FPR ; FORMYL-PEPTIDE RECEPTORS ; NF-KAPPA-B ; IN-VIVO ; GENE-EXPRESSION ; MAMMALIAN-CELLS ; DENDRITIC CELLS ; BREAST-CANCER ; SIRNA DESIGN |
| WOS研究方向 | Immunology ; Pharmacology & Pharmacy |
| WOS类目 | Immunology ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000245145400002 |
| 出版者 | ELSEVIER SCIENCE BV |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2382578 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Le, Yingying |
| 作者单位 | 1.Chinese Acad Sci, Grad Sch, Shanghai Inst Biol Sci, Inst Nutr Sci,Lab Immunol & Inflammatory Dis, Shanghai, Peoples R China 2.NCI, Canc Res Ctr, Mol Immunoregulat Lab, Frederick, MD 21701 USA |
| 推荐引用方式 GB/T 7714 | Kong, Yan,Ruan, Lingfei,Ma, Lili,et al. Rna interference as a novel and powerful tool in immunopharmacological research[J]. International immunopharmacology,2007,7(4):417-426. |
| APA | Kong, Yan,Ruan, Lingfei,Ma, Lili,Cui, Youhong,Wang, Ji Ming,&Le, Yingying.(2007).Rna interference as a novel and powerful tool in immunopharmacological research.International immunopharmacology,7(4),417-426. |
| MLA | Kong, Yan,et al."Rna interference as a novel and powerful tool in immunopharmacological research".International immunopharmacology 7.4(2007):417-426. |
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来源：中国科学院大学
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