Enantiocomplementary preparation of (s)- and (r)-mandelic acid derivatives via alpha-hydroxylation of 2-arylacetic acid derivatives and reduction of alpha-ketoester using microbial whole cells
文献类型：期刊论文
| 作者 | Chen, Yongzheng1,2; Xu, Jinggang; Xu, Xiaoying1; Xia, Yu1; Lin, Hui1; Xia, Shiwen1; Wang, Lixin1 |
| 刊名 | Tetrahedron-asymmetry
 |
| 出版日期 | 2007-10-22 |
| 卷号 | 18期号:21页码:2537-2540 |
| ISSN号 | 0957-4166 |
| DOI | 10.1016/j.tetasy.2007.09.029 |
| 通讯作者 | Xia, shiwen(swxia2008@hotmail.com) |
| 英文摘要 | Forty one microorganisms belonging to different taxonomical groups were used to carry out the enantio selective reduction of methyl benzoylformate to afford the corresponding (r)-methyl mandelate, with moderate to high ee. in contrast, the monooxygenase enzyme in helminthosporium sp. cioc3.3316 catalyzed the hydroxylation of methyl 2-phenylacetate to (s)-methyl mandelate. this combination of oxidation and reduction biotransformations thus provides a method for preparing the enantiomers of chiral alpha-hydroxy acid derivatives. (c) 2007 elsevier ltd. all rights reserved. |
| WOS关键词 | DYNAMIC KINETIC RESOLUTION ; CARBOXYLIC-ACIDS ; ASYMMETRIC REDUCTION ; CARBONYL REDUCTASE ; GREEN CHEMISTRY ; ENZYMES |
| WOS研究方向 | Chemistry |
| WOS类目 | Chemistry, Inorganic & Nuclear ; Chemistry, Organic ; Chemistry, Physical |
| 语种 | 英语 |
| WOS记录号 | WOS:000251621600007 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2382652 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Xia, Shiwen |
| 作者单位 | 1.Chinese Acad Sci, Chengdu Inst Organ Chem, Key Lab Asymmetr Synth & Chirotechnol Sichuan Pro, Chengdu 610041, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Yongzheng,Xu, Jinggang,Xu, Xiaoying,et al. Enantiocomplementary preparation of (s)- and (r)-mandelic acid derivatives via alpha-hydroxylation of 2-arylacetic acid derivatives and reduction of alpha-ketoester using microbial whole cells[J]. Tetrahedron-asymmetry,2007,18(21):2537-2540. |
| APA | Chen, Yongzheng.,Xu, Jinggang.,Xu, Xiaoying.,Xia, Yu.,Lin, Hui.,...&Wang, Lixin.(2007).Enantiocomplementary preparation of (s)- and (r)-mandelic acid derivatives via alpha-hydroxylation of 2-arylacetic acid derivatives and reduction of alpha-ketoester using microbial whole cells.Tetrahedron-asymmetry,18(21),2537-2540. |
| MLA | Chen, Yongzheng,et al."Enantiocomplementary preparation of (s)- and (r)-mandelic acid derivatives via alpha-hydroxylation of 2-arylacetic acid derivatives and reduction of alpha-ketoester using microbial whole cells".Tetrahedron-asymmetry 18.21(2007):2537-2540. |
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来源：中国科学院大学
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