Scanning for signatures of geographically restricted selection based on population genomics analysis
文献类型：期刊论文
| 作者 | Deng LiBin; Tang XiaoLi; Kang Jian; Wang QingYun; Zeng ChangQing |
| 刊名 | Chinese science bulletin
 |
| 出版日期 | 2007-10-01 |
| 卷号 | 52期号:19页码:2649-2656 |
| 关键词 | Natural selection Hapmap project Single nucleotide polymorphism Population genomics Gene ontology |
| ISSN号 | 1001-6538 |
| DOI | 10.1007/s11434-007-0400-0 |
| 通讯作者 | Zeng changqing(czeng@genomics.org.cn) |
| 英文摘要 | Natural selection, as the driving force of human evolution, has direct impact on population differentiation. however, it is still unclear to what extent the genetic differentiation has been caused by natural selection. to explore this question, we performed a genome-wide scan with single nucleotide polymorphism (snp) data from the international hapmap project. single locus f (st) analysis was applied to assess the frequency difference among populations in autosomes. based on the empirical distribution of f (st), we identified 12669 snps correlating to population differentiation and 1853 candidate genes subjected to geographic restricted natural selection. further interpretation of gene ontogeny revealed 121 categories of biological process with the enrichments of candidate genes. our results suggest that natural selection may play an important role in human population differentiation. in addition, our analysis provides new clues as well as research methods for our understanding of population differentiation and natural selection. |
| WOS关键词 | INTERNATIONAL HAPMAP PROJECT ; NATURAL-SELECTION ; POSITIVE SELECTION ; SEQUENCE VARIATION ; EVOLUTION ; GENE ; HUMANS ; SCANS ; HISTORY ; MAP |
| WOS研究方向 | Science & Technology - Other Topics |
| WOS类目 | Multidisciplinary Sciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000249915600011 |
| 出版者 | SCIENCE CHINA PRESS |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2382706 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Zeng ChangQing |
| 作者单位 | 1.Chinese Acad Sci, Beijing Inst Genom, Beijing 101300, Peoples R China 2.Grad Univ, Chinese Acad Sci, Beijing 100049, Peoples R China 3.Tsing Hua Univ, Sch Sci, Dept Math Sci, Beijing 100084, Peoples R China 4.Beijing Normal Univ, Sch Math Sci, Beijing 100875, Peoples R China |
| 推荐引用方式 GB/T 7714 | Deng LiBin,Tang XiaoLi,Kang Jian,et al. Scanning for signatures of geographically restricted selection based on population genomics analysis[J]. Chinese science bulletin,2007,52(19):2649-2656. |
| APA | Deng LiBin,Tang XiaoLi,Kang Jian,Wang QingYun,&Zeng ChangQing.(2007).Scanning for signatures of geographically restricted selection based on population genomics analysis.Chinese science bulletin,52(19),2649-2656. |
| MLA | Deng LiBin,et al."Scanning for signatures of geographically restricted selection based on population genomics analysis".Chinese science bulletin 52.19(2007):2649-2656. |
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来源：中国科学院大学
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