Effect of vanadate on gene expression of the insulin signaling pathway in skeletal muscle of streptozotocin-induced diabetic rats
文献类型：期刊论文
| 作者 | Wei, Dan; Li, Ming; Ding, Wenjun |
| 刊名 | Journal of biological inorganic chemistry
 |
| 出版日期 | 2007-11-01 |
| 卷号 | 12期号:8页码:1265-1273 |
| 关键词 | Diabetes Vanadium Insulin signaling pathway Microarray |
| ISSN号 | 0949-8257 |
| DOI | 10.1007/s00775-007-0294-y |
| 通讯作者 | Ding, wenjun(dingwj@gucas.ac.cn) |
| 英文摘要 | An insulin signaling pathway microarray was used to evaluate the gene expression profiling of the insulin signaling pathway in the skeletal muscle of streptozotocin-induced diabetic, navo3-treated diabetic and insulin-treated diabetic rats for the investigation of the effect of vanadium and insulin on the insulin signaling pathway. of 96 genes surveyed, transcriptional patterns of 19 genes (20%) showed alterations in diabetic rats compared with controls. although most of these changed gene expressions were improved after treatment with navo3 (14, 74%) and insulin (16, 84%), navo3 and insulin treatment resulted in the alteration of 20 and 12 additional gene transcripts compared no treatment. we found that both navo3 and insulin treatment achieved a desirable glucose level and most of the alterative gene transcripts in diabetic rats were normalized with navo3 and insulin treatment. comparison of the gene expression profiling indicates that there is a significant difference between the navo3-treated group and the insulin-treated group. the present study demonstrated for the first time that several candidate genes of the insulin signaling pathway are involved in the effect of vanadium treatment on hyperglycemia. this study opens the way for more focused investigations that may identify the genes responsible for diabetes and vanadium treatment in the global insulin signaling pathway. |
| WOS关键词 | OSTEOBLAST-LIKE CELLS ; GLUCOSE-METABOLISM ; PHOSPHATIDYLINOSITOL 3-KINASE ; PHOSPHATASE INHIBITOR ; GLYCOGEN-SYNTHESIS ; RECEPTOR-BINDING ; VANADIUM SALTS ; FATTY RATS ; IN-VITRO ; SULFATE |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
| WOS类目 | Biochemistry & Molecular Biology ; Chemistry, Inorganic & Nuclear |
| 语种 | 英语 |
| WOS记录号 | WOS:000250206100015 |
| 出版者 | SPRINGER |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2382801 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Ding, Wenjun |
| 作者单位 | Grad Univ, Chinese Acad Sci, Dept Biol, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wei, Dan,Li, Ming,Ding, Wenjun. Effect of vanadate on gene expression of the insulin signaling pathway in skeletal muscle of streptozotocin-induced diabetic rats[J]. Journal of biological inorganic chemistry,2007,12(8):1265-1273. |
| APA | Wei, Dan,Li, Ming,&Ding, Wenjun.(2007).Effect of vanadate on gene expression of the insulin signaling pathway in skeletal muscle of streptozotocin-induced diabetic rats.Journal of biological inorganic chemistry,12(8),1265-1273. |
| MLA | Wei, Dan,et al."Effect of vanadate on gene expression of the insulin signaling pathway in skeletal muscle of streptozotocin-induced diabetic rats".Journal of biological inorganic chemistry 12.8(2007):1265-1273. |
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来源：中国科学院大学
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