Biotransformation of deoxyaconitine of metabolite of aconitine by human intestinal bacteria and electrospray ionization tandem mass spectrometry
文献类型：期刊论文
| 作者 | Zhao Yu-Feng; Song Feng-Rui; Yue Hao; Guo Xin-Hua; Li Hui-Lin; Liu Zhi-Qiang; Liu Shu-Ying |
| 刊名 | Chemical journal of chinese universities-chinese
 |
| 出版日期 | 2007-11-10 |
| 卷号 | 28期号:11页码:2051-2055 |
| 关键词 | Deoxyaconitine Human intestinal bacteria Biotransformation Electrospray ionization tandem Mass spectrometry |
| ISSN号 | 0251-0790 |
| 通讯作者 | Liu shu-ying() |
| 英文摘要 | To study the biotransformation of deoxyaconitine in intestine, aconitine was incubated with human intestinal bacteria in vitro. the metabolites of deoxyaconitine were investigated by ion trap and fourier transform ion cyclotron resonance electrospray ionization tandem mass spectrometry directly. aconitine and its metabolites formed the protonated molecular ion [m + h](+) in the positive ion mode. according to the m/z of [m + h] (+), the molecular weight of the metabolite was determined and the structure was characterized by using msn and the data in literature. the results show that deoxyaconitine could be transformed by human intestinal bacteria. deoxyaconitine was converted into more than ten kinds of new metabolites such as mono-ester aconitum alkaloids, diester aconitines and lipo-alkaloids by deacetylation, debenzoylation, dehydroxylation, demethylation and esterification. diester deoxyaconitine is very toxic. when deoxyaconitine was transformed into mono-ester aconitum alkaloids and lipo-alkaloids by human intestinal bacteria, the toxicity decreased. |
| WOS关键词 | CARMIECHAELI |
| WOS研究方向 | Chemistry |
| WOS类目 | Chemistry, Multidisciplinary |
| 语种 | 英语 |
| WOS记录号 | WOS:000251121800007 |
| 出版者 | HIGHER EDUCATION PRESS |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2383088 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Liu Shu-Ying |
| 作者单位 | 1.Chinese Acad Sci, Changchun Inst Appl Chem, Changchun 130022, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhao Yu-Feng,Song Feng-Rui,Yue Hao,et al. Biotransformation of deoxyaconitine of metabolite of aconitine by human intestinal bacteria and electrospray ionization tandem mass spectrometry[J]. Chemical journal of chinese universities-chinese,2007,28(11):2051-2055. |
| APA | Zhao Yu-Feng.,Song Feng-Rui.,Yue Hao.,Guo Xin-Hua.,Li Hui-Lin.,...&Liu Shu-Ying.(2007).Biotransformation of deoxyaconitine of metabolite of aconitine by human intestinal bacteria and electrospray ionization tandem mass spectrometry.Chemical journal of chinese universities-chinese,28(11),2051-2055. |
| MLA | Zhao Yu-Feng,et al."Biotransformation of deoxyaconitine of metabolite of aconitine by human intestinal bacteria and electrospray ionization tandem mass spectrometry".Chemical journal of chinese universities-chinese 28.11(2007):2051-2055. |
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来源：中国科学院大学
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