Thermogenesis, food intake and serum leptin in cold-exposed lactating brandt's voles lasiopodomys brandtii
文献类型：期刊论文
| 作者 | Zhang, Xue-Ying; Wang, De-Hua |
| 刊名 | Journal of experimental biology
 |
| 出版日期 | 2007-02-01 |
| 卷号 | 210期号:3页码:512-521 |
| 关键词 | Brandt's vole Lasiopodomys brandtii Cold exposure Food intake Lactation Serum leptin Uncoupling protein 1 (ucp1) |
| ISSN号 | 0022-0949 |
| DOI | 10.1242/jeb.02659 |
| 通讯作者 | Wang, de-hua(wangdh@ioz.ac.cn) |
| 英文摘要 | Lactation is the most energetically expensive period for mammals and is associated with increased metabolism and energy intake, but decreased thermogenic capacity. it is well known that small mammals increase both food intake and thermogenesis in the cold. the present study aimed to examine whether brandt's voles lasiopodomys brandtii could adjust energy intake and thermogenesis to accommodate simultaneous lactation and cold exposure. the voles were placed into two temperature treatments: warm (23 +/- 1 degrees c) and cold (5 +/- 1 degrees c). animals at each temperature treatment were further divided into two groups: non-reproductive (nr) and lactating females. we found that lactating voles at peak lactation in the cold enhanced food intake by 2.6 g day(-1) compared with those in the warm, and increased uncoupling protein 1 (ucp1) content in brown adipose tissue (bat), to the same level as the cold-exposed nr females. serum leptin levels decreased significantly during lactation and were positively correlated with body mass and fat mass. after correcting for the effects of body mass, residual serum leptin was negatively correlated with residual gross energy intake and residual rmr. in addition, residual serum leptin levels were positively correlated with ucp1 contents in the warm, but not in the cold. together, these data suggest that lactating voles can increase thermogenic capacity and energy intake to meet the high energetic costs of simultaneous lactation and cold exposure. further, serum leptin appears to be involved in the energy intake regulation and thermoregulation, but the thermoregulation in the cold may be mainly mediated by other factors. |
| WOS关键词 | BROWN ADIPOSE-TISSUE ; ENERGY-INTAKE ; MUS MUSCULUS ; BODY-WEIGHT ; MICROTUS-BRANDTII ; GROUND-SQUIRRELS ; METABOLIC-RATE ; PLASMA LEPTIN ; LIMITS ; RATS |
| WOS研究方向 | Life Sciences & Biomedicine - Other Topics |
| WOS类目 | Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000244083300024 |
| 出版者 | COMPANY OF BIOLOGISTS LTD |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2383101 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Wang, De-Hua |
| 作者单位 | 1.Chinese Acad Sci, Inst Zool, State Key Lab Integrated Management Pest Insects, Beijing 100080, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Xue-Ying,Wang, De-Hua. Thermogenesis, food intake and serum leptin in cold-exposed lactating brandt's voles lasiopodomys brandtii[J]. Journal of experimental biology,2007,210(3):512-521. |
| APA | Zhang, Xue-Ying,&Wang, De-Hua.(2007).Thermogenesis, food intake and serum leptin in cold-exposed lactating brandt's voles lasiopodomys brandtii.Journal of experimental biology,210(3),512-521. |
| MLA | Zhang, Xue-Ying,et al."Thermogenesis, food intake and serum leptin in cold-exposed lactating brandt's voles lasiopodomys brandtii".Journal of experimental biology 210.3(2007):512-521. |
入库方式： iSwitch采集
来源：中国科学院大学
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。