Analytical strategies in lipidomics and applications in disease biomarker discovery
文献类型：期刊论文
| 作者 | Hu, Chunxiu1,2; van der Heijden, Rob2; Wang, Mei3; van der Greef, Jan2,3; Hankemeier, Thomas2; Xua, Guowang1 |
| 刊名 | journal of chromatography b-analytical technologies in the biomedical and life sciences
 |
| 出版日期 | 2009-09-15 |
| 卷号 | 877期号:26页码:2836-2846 |
| 关键词 | Lipidomics Lipid-associated disorders Biomarkers Lipid profiling |
| 产权排序 | 1;1 |
| 通讯作者 | 许国旺 |
| 英文摘要 | lipidomics is a lipid-targeted metabolomics approach aiming at comprehensive analysis of lipids in biological systems. recently, lipid profiling, or so-called lipidomics research, has captured increased attention due to the well-recognized roles of lipids in numerous human diseases to which lipid-associated disorders contribute, such as diabetes, obesity, atherosclerosis and alzheimer's disease. investigating lipid biochemistry using a lipidomics approach will not only provide insights into the specific roles of lipid molecular species in health and disease, but will also assist in identifying potential biomarkers for establishing preventive or therapeutic approaches for human health. recent technological advancements in mass spectrometry and rapid improvements in chromatographic techniques have led to the rapid expansion of the lipidomics research held. in this review, emphasis is given to the recent advances in lipidomics technologies and their applications in disease biomarker discovery. (c) 2009 elsevier b.v. all rights reserved. |
| WOS标题词 | science & technology ; life sciences & biomedicine ; physical sciences |
| 类目[WOS] | biochemical research methods ; chemistry, analytical |
| 研究领域[WOS] | biochemistry & molecular biology ; chemistry |
| 关键词[WOS] | performance liquid-chromatography ; ionization mass-spectrometry ; assisted laser-desorption ; multivariate statistical-analysis ; maldi-tof ms ; shotgun lipidomics ; cellular lipidomes ; biological samples ; lipoprotein metabolism ; phospholipid profiles |
| 收录类别 | SCI |
| 原文出处 | false |
| 语种 | 英语 |
| WOS记录号 | WOS:000269224200017 |
| 公开日期 | 2010-11-30 |
| 源URL | [http://159.226.238.44/handle/321008/102165]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China 2.Leiden Univ, Div Analyt Biosci, LACDR, NL-2300 RA Leiden, Netherlands 3.SU BioMed & TNO Qual Life, NL-3700 AJ Zeist, Netherlands |
| 推荐引用方式 GB/T 7714 | Hu, Chunxiu,van der Heijden, Rob,Wang, Mei,et al. Analytical strategies in lipidomics and applications in disease biomarker discovery[J]. journal of chromatography b-analytical technologies in the biomedical and life sciences,2009,877(26):2836-2846. |
| APA | Hu, Chunxiu,van der Heijden, Rob,Wang, Mei,van der Greef, Jan,Hankemeier, Thomas,&Xua, Guowang.(2009).Analytical strategies in lipidomics and applications in disease biomarker discovery.journal of chromatography b-analytical technologies in the biomedical and life sciences,877(26),2836-2846. |
| MLA | Hu, Chunxiu,et al."Analytical strategies in lipidomics and applications in disease biomarker discovery".journal of chromatography b-analytical technologies in the biomedical and life sciences 877.26(2009):2836-2846. |
入库方式： OAI收割
来源：大连化学物理研究所
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