Mapping the c-elegans noncoding transcriptome with a whole-genome tiling microarray
文献类型：期刊论文
| 作者 | He, Housheng; Wang, Jie; Liu, Tao; Liu, X. Shirley; Li, Tiantian; Wang, Yunfei; Qian, Zuwei; Zheng, Haixia; Zhu, Xiaopeng; Wu, Tao |
| 刊名 | Genome research
 |
| 出版日期 | 2007-10-01 |
| 卷号 | 17期号:10页码:1471-1477 |
| ISSN号 | 1088-9051 |
| DOI | 10.1101/gr.661807 |
| 通讯作者 | Zhu, xiaopeng(crs@sun5.ibp.ac.cn) |
| 英文摘要 | The number of annotated protein coding genes in the genome of caenorhabditis elegans is similar to that of other animals, but the extent of its non- protein- coding transcriptome remains unknown. expression profiling on whole- genome tiling microarrays applied to a mixed- stage c. elegans population verified the expression of 71% of all annotated exons. only a small fraction ( 11%) of the polyadenylated transcription is non- annotated and appears to consist of similar to 3200 missed or alternative exons and 7800 small transcripts of unknown function ( tufs). almost half ( 44%) of the detected transcriptional output is non- polyadenylated and probably not protein coding, and of this, 70% overlaps the boundaries of protein- coding genes in a complex manner. specific analysis of small non- polyadenylated transcripts verified 97% of all annotated small ncrnas and suggested that the transcriptome contains similar to 1200 small (< 500 nt) unannotated noncoding loci. after combining overlapping transcripts, we estimate that at least 70% of the total c. elegans genome is transcribed. |
| WOS关键词 | CAENORHABDITIS-ELEGANS ; GENE-EXPRESSION ; RNAS ; RESOLUTION ; SEQUENCES ; ARRAYS ; DNA ; IDENTIFICATION ; NEMATODES ; BRIGGSAE |
| WOS研究方向 | Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology ; Genetics & Heredity |
| WOS类目 | Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology ; Genetics & Heredity |
| 语种 | 英语 |
| WOS记录号 | WOS:000249869200008 |
| 出版者 | COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2383342 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Zhu, Xiaopeng |
| 作者单位 | 1.Chinese Acad Sci, Inst Biophys, Bioinformat Lab, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Inst Biophys, Natl Lab Biomacromol, Beijing 100101, Peoples R China 3.Chinese Acad Sci, Grad Sch, Beijing 100080, Peoples R China 4.Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Biostat & Computat Biol, Boston, MA 02115 USA 5.Harvard Univ, Sch Publ Hlth, Boston, MA 02115 USA 6.Affymetrix Inc, Santa Clara, CA 95051 USA 7.Chinese Acad Sci, Inst Comp Technol, Key Lab Intelligent Informat Proc, Bioinformat Res Grp, Beijing 100080, Peoples R China 8.Chinese Natl Human Genome Ctr, Beijing 100176, Peoples R China |
| 推荐引用方式 GB/T 7714 | He, Housheng,Wang, Jie,Liu, Tao,et al. Mapping the c-elegans noncoding transcriptome with a whole-genome tiling microarray[J]. Genome research,2007,17(10):1471-1477. |
| APA | He, Housheng.,Wang, Jie.,Liu, Tao.,Liu, X. Shirley.,Li, Tiantian.,...&Chen, Runsheng.(2007).Mapping the c-elegans noncoding transcriptome with a whole-genome tiling microarray.Genome research,17(10),1471-1477. |
| MLA | He, Housheng,et al."Mapping the c-elegans noncoding transcriptome with a whole-genome tiling microarray".Genome research 17.10(2007):1471-1477. |
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来源：中国科学院大学
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