Protective effects of green tea polyphenols in the 6-ohda rat model of parkinson's disease through inhibition of ros-no pathway
文献类型：期刊论文
| 作者 | Guo, Shuhong; Yan, Jingqi; Yang, Tangbin; Yang, Xianqiang; Bezard, Erwan; Zhao, Baolu |
| 刊名 | Biological psychiatry
 |
| 出版日期 | 2007-12-15 |
| 卷号 | 62期号:12页码:1353-1362 |
| 关键词 | Electron spin resonance Natural antioxidants Neurodegenerative disease Nitric oxide Reactive oxygen species Stereology |
| ISSN号 | 0006-3223 |
| DOI | 10.1016/j.biopsych.2007.04.020 |
| 通讯作者 | Zhao, baolu(zhaobl@sun5.ibp.ac.cn) |
| 英文摘要 | Background: nitric oxide (no) and related pathways are thought to play an important role in the pathogenesis of parkinson's disease (pd). our in vitro experiments suggested that green tea polyphenols (gtp) might protect dopamine neurons through inhibition of no and reactive oxygen species (ros). methods: immunohistochemistry, terminal deoxynucleotidyl transferase-mediated dutp nick end labeling assay, electron spin resonance spin trapping, enzyme linked immunosorbent assay, and molecular biological methods were used to investigate the effects of gtp in an unilateral 6-hydroxydopamine (6-ohda)-treated rat model of pd. results: gtp treatment dose-dependently protected dopaminergic neurons by preventing from midbrain and striatal 6-ohda-induced increase in 1) both ros and no levels, 2) lipid peroxidation, 3) nitrite/nitrate content, 4) inducible nitric oxide synthase, and 5) protein-bound 3-nitro-tyrosine. moreover, gtp treatment dose-dependently preserved the free radical scavenging capability of both the midbrain and the striatum. conclusions: these results support the in vivo protection of gtp against 6-ohda and suggest that gtp treatment might represent a neuroprotective treatment of pd. |
| WOS关键词 | NITRIC-OXIDE SYNTHASE ; HIGH-FREQUENCY STIMULATION ; SUBSTANTIA-NIGRA ; SH-SY5Y CELLS ; SUBTHALAMIC NUCLEUS ; INDUCED APOPTOSIS ; BASAL GANGLIA ; MPTP TOXICITY ; ANIMAL-MODELS ; TOTAL NUMBER |
| WOS研究方向 | Neurosciences & Neurology ; Psychiatry |
| WOS类目 | Neurosciences ; Psychiatry |
| 语种 | 英语 |
| WOS记录号 | WOS:000251496400005 |
| 出版者 | ELSEVIER SCIENCE INC |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2383401 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Zhao, Baolu |
| 作者单位 | 1.Acad Sinica, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China 3.CNRS, Bordeaux, France 4.Inst Space & Med Engn, Space Cell & Mol Biol Lab, Beijing, Peoples R China 5.Zhejiang Univ, Dept Tea Sci, Hangzhou 310027, Peoples R China 6.Shanghai Municipal Educ Commiss, E Inst, Shanghai, Peoples R China |
| 推荐引用方式 GB/T 7714 | Guo, Shuhong,Yan, Jingqi,Yang, Tangbin,et al. Protective effects of green tea polyphenols in the 6-ohda rat model of parkinson's disease through inhibition of ros-no pathway[J]. Biological psychiatry,2007,62(12):1353-1362. |
| APA | Guo, Shuhong,Yan, Jingqi,Yang, Tangbin,Yang, Xianqiang,Bezard, Erwan,&Zhao, Baolu.(2007).Protective effects of green tea polyphenols in the 6-ohda rat model of parkinson's disease through inhibition of ros-no pathway.Biological psychiatry,62(12),1353-1362. |
| MLA | Guo, Shuhong,et al."Protective effects of green tea polyphenols in the 6-ohda rat model of parkinson's disease through inhibition of ros-no pathway".Biological psychiatry 62.12(2007):1353-1362. |
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来源：中国科学院大学
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