Dissecting the signaling pathway of nicotine-mediated neuroprotection in a mouse alzheimer disease model
文献类型：期刊论文
| 作者 | Liu, Qiang; Zhang, Jie; Zhu, Hua; Qin, Chuan; Chen, Qi; Zhao, Baolu |
| 刊名 | Faseb journal
 |
| 出版日期 | 2007 |
| 卷号 | 21期号:1页码:61-73 |
| 关键词 | Ad Alpha 7nachrs Signal pathway |
| ISSN号 | 0892-6638 |
| DOI | 10.1096/fj.06-5841com |
| 通讯作者 | Zhao, baolu(zhaobl@sun5.ibp.ac.cn) |
| 英文摘要 | Nicotine has a therapeutic benefit in treating alzheimer's disease ( ad). in the present study we show that nicotine decreases accumulation of beta-amyloid ( a beta) in the cortex and hippocampus of app ( v717i) transgenic mice. nicotine prevents activation of nf-kappa b and c-myc by inhibiting the activation of map kinases ( mapks). as a result, the activity of inducible nos and the production of no are down-regulated. rna interference experiments show that the above nicotine-mediated process requires alpha 7 nachr. nicotine decreases a beta via the activation of alpha 7nachrs through mapk, nf-kappa b, and c-myc pathways. nicotine also inhibits apoptosis and cell cycle progression in this mouse line. the dissected signaling pathway of nicotine-mediated neuroprotection in the present study provides a mechanistic basis for the potential development of drug targets for treating ad. |
| WOS关键词 | AMYLOID PRECURSOR PROTEIN ; PROGRESSIVE SUPRANUCLEAR PALSY ; ACETYLCHOLINE-RECEPTOR ; INDUCED NEUROTOXICITY ; CELL-DEATH ; NEURODEGENERATIVE DISEASES ; MICROGLIAL ACTIVATION ; INHIBITS APOPTOSIS ; TEMPORAL CORTEX ; PICKS-DISEASE |
| WOS研究方向 | Biochemistry & Molecular Biology ; Life Sciences & Biomedicine - Other Topics ; Cell Biology |
| WOS类目 | Biochemistry & Molecular Biology ; Biology ; Cell Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000243130200008 |
| 出版者 | FEDERATION AMER SOC EXP BIOL |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2383437 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Zhao, Baolu |
| 作者单位 | 1.Acad Sinica, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China 3.Chinese Acad Sci, Inst Lab Anim Sci, Beijing, Peoples R China 4.Salk Inst Biol Studies, La Jolla, CA 92037 USA 5.Shanghai Univ Tradit Chinese Med, E Inst NO & Inflammat, Shanghai, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Qiang,Zhang, Jie,Zhu, Hua,et al. Dissecting the signaling pathway of nicotine-mediated neuroprotection in a mouse alzheimer disease model[J]. Faseb journal,2007,21(1):61-73. |
| APA | Liu, Qiang,Zhang, Jie,Zhu, Hua,Qin, Chuan,Chen, Qi,&Zhao, Baolu.(2007).Dissecting the signaling pathway of nicotine-mediated neuroprotection in a mouse alzheimer disease model.Faseb journal,21(1),61-73. |
| MLA | Liu, Qiang,et al."Dissecting the signaling pathway of nicotine-mediated neuroprotection in a mouse alzheimer disease model".Faseb journal 21.1(2007):61-73. |
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来源：中国科学院大学
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