Role of ppar gamma and its gonadotrophic regulation in rat ovarian granulosa cells in vitro
文献类型：期刊论文
| 作者 | Zhang, Heng; Li, Qinglei; Lin, Haiyan; Yang, Qing; Wang, Hongmei; Zhu, Cheng |
| 刊名 | Neuroendocrinology letters
 |
| 出版日期 | 2007-06-01 |
| 卷号 | 28期号:3页码:289-294 |
| 关键词 | Ppar gamma Granulosa cells Proliferation Apoptosis Steroidogenesis |
| ISSN号 | 0172-780X |
| 通讯作者 | Zhu, cheng(zhuc@ioz.ac.cn) |
| 英文摘要 | The peroxisome proliferator-activated receptors (ppars), including ppar alpha, ppar beta/delta, and ppar gamma, are a family of transcription factors belonging to the steroid receptor superfamily. in rat ovary, ppar gamma is mainly expressed in granulosa cells of developing follicles, implying a possible role of ppar gamma in ovarian functions. in the present study, the role of ppar gamma and its gonadotrophic regulation in granulosa cells collected from diethylstilbestrol-treated immature rats were studied. the results showed that ppar gamma could inhibit proliferation and induce apoptosis in primarily cultured granulosa cells. ppar gamma could also stimulate the biosynthesis of estradiol and progesterone after fsh pretreatment, and fsh could regulate the functions of ppar gamma through pka, erk1/2, and p38 mapk signaling pathways. these data suggested that ppar gamma may be involved in follicular atresia and fsh-stimulated steroidogenesis during follicle development. |
| WOS关键词 | PROLIFERATOR-ACTIVATED RECEPTORS ; FOLLICLE-STIMULATING-HORMONE ; KINASE-MEDIATED PHOSPHORYLATION ; RETINOIC ACID ; DIFFERENTIATION ; EXPRESSION ; PATHWAY ; ADIPOGENESIS ; TROGLITAZONE ; INHIBITION |
| WOS研究方向 | Endocrinology & Metabolism ; Neurosciences & Neurology |
| WOS类目 | Endocrinology & Metabolism ; Neurosciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000247920000014 |
| 出版者 | MAGHIRA & MAAS PUBLICATIONS |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2383443 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Zhu, Cheng |
| 作者单位 | 1.Chinese Acad Sci, Inst Zool, State Key Lab Reprod Biol, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100101, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Heng,Li, Qinglei,Lin, Haiyan,et al. Role of ppar gamma and its gonadotrophic regulation in rat ovarian granulosa cells in vitro[J]. Neuroendocrinology letters,2007,28(3):289-294. |
| APA | Zhang, Heng,Li, Qinglei,Lin, Haiyan,Yang, Qing,Wang, Hongmei,&Zhu, Cheng.(2007).Role of ppar gamma and its gonadotrophic regulation in rat ovarian granulosa cells in vitro.Neuroendocrinology letters,28(3),289-294. |
| MLA | Zhang, Heng,et al."Role of ppar gamma and its gonadotrophic regulation in rat ovarian granulosa cells in vitro".Neuroendocrinology letters 28.3(2007):289-294. |
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来源：中国科学院大学
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