A modular network model of aging
文献类型：期刊论文
| 作者 | Xue, Huiling1,2; Xian, Bo1,2; Dong, Dong1; Xia, Kai1; Zhu, Shanshan1; Zhang, Zhongnan1; Hou, Lei1; Zhang, Qingpeng1; Zhang, Yi1; Han, Jing-Dong J.1 |
| 刊名 | Molecular systems biology
 |
| 出版日期 | 2007-12-01 |
| 卷号 | 3页码:11 |
| 关键词 | Aging Cell metabolisms Differentiation Module Network Regulation Stability Proliferation |
| ISSN号 | 1744-4292 |
| DOI | 10.1038/msb4100189 |
| 通讯作者 | Han, jing-dong j.(jdhan@genetics.ac.cn) |
| 英文摘要 | Many fundamental questions on aging are still unanswered or are under intense debate. these questions are frequently not addressable by examining a single gene or a single pathway, but can best be addressed at the systems level. here we examined the modular structure of the protein protein interaction (ppi) networks during fruitfly and human brain aging. in both networks, there are two modules associated with the cellular proliferation to differentiation temporal switch that display opposite aging-related changes in expression. during fly aging, another couple of modules are associated with the oxidative-reductive metabolic temporal switch. these network modules and their relationships demonstrate (1) that aging is largely associated with a small number, instead of many network modules, (2) that some modular changes might be reversible and (3) that genes connecting different modules through ppis are more likely to affect aging/longevity, a conclusion that is experimentally validated by caenorhabditis elegans lifespan analysis. network simulations further suggest that aging might preferentially attack key regulatory nodes that are important for the network stability, implicating a potential molecular basis for the stochastic nature of aging. |
| WOS关键词 | PROTEIN INTERACTION NETWORK ; GENE-EXPRESSION ; C-ELEGANS ; TRANSCRIPTIONAL PROFILE ; DROSOPHILA-MELANOGASTER ; CAENORHABDITIS-ELEGANS ; SYSTEMS BIOLOGY ; MAP ; LONGEVITY ; CYCLE |
| WOS研究方向 | Biochemistry & Molecular Biology |
| WOS类目 | Biochemistry & Molecular Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000252119000001 |
| 出版者 | NATURE PUBLISHING GROUP |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2383471 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Han, Jing-Dong J. |
| 作者单位 | 1.Chinese Acad Sci, Inst Gen & Dev Biol, Ctr Mol Syst Biol, Chinese Acad Sci Key Lab Mol & Dev Biol, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xue, Huiling,Xian, Bo,Dong, Dong,et al. A modular network model of aging[J]. Molecular systems biology,2007,3:11. |
| APA | Xue, Huiling.,Xian, Bo.,Dong, Dong.,Xia, Kai.,Zhu, Shanshan.,...&Han, Jing-Dong J..(2007).A modular network model of aging.Molecular systems biology,3,11. |
| MLA | Xue, Huiling,et al."A modular network model of aging".Molecular systems biology 3(2007):11. |
入库方式： iSwitch采集
来源：中国科学院大学
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。