In vivo Inhibition of S180 Tumors by the Synergistic Effect of the Chinese Medicinal Herbs Coptis chinensis and Evodia rutaecarpa
文献类型：期刊论文
| 作者 | Wang, Xiao-na2; Xu, Li-na2; Peng, Jin-yong1,2; Liu, Ke-xin2; Zhang, Li-hua1; Zhang, Yu-kui1 |
| 刊名 | planta medica
 |
| 出版日期 | 2009-09-01 |
| 卷号 | 75期号:11页码:1215-1220 |
| 关键词 | Coptis chinensis Franch Evodia rutaecarpa (Juss.) Benth Zuojinwan synergy Ranunculaceae Rutaceae |
| 产权排序 | 2;3 |
| 通讯作者 | 彭金咏 ; 张丽华 |
| 英文摘要 | the aim of the present paper was to investigate the synergistic effect and mechanism of anticancer activity of zuojinwan (zjw) comprising coptis chinensis franch (hl) and evodia rutaecarpa (juss.) benth (wzy) at a ratio of 6: 1 (w/w). in vivo anticancer activity testing was carried out by inhibiting the growth of s180 tumor. tumor growth inhibition, spleen index, lymphocyte proliferation, apoptosis, tumor necrosis factor-alpha (tnf-alpha) level, activities of serum tumor markers (tms), increase in life span (ils), histopathology and gene expression were tested. the results indicated that zjw could significantly induce apoptosis of cancer cells. the inhibition ratio, ils and tnf-alpha levels of mice treated with zjw were 50.54%, 64.91% and 1.04 ng/ml, respectively, much higher than hl and wzy when singly used. furthermore, the activities of acid phosphatase and alkaline phosphatase were significantly increased and the activities of creatine kinase, aldolase and lactate dehydrogenase were reduced in serum, and the expressions of bax and wild-type p53 proteins were much higher for the mice treated by zjw compared with hl and wzy single-treatment groups. a clear synergistic effect on the anticancer activity was observed with zjw, and the mechanism of antitumor growth may be due to an effect on gene expression and activities of tumor markers in serum. |
| WOS标题词 | science & technology ; life sciences & biomedicine |
| 类目[WOS] | plant sciences ; chemistry, medicinal ; pharmacology & pharmacy |
| 研究领域[WOS] | plant sciences ; pharmacology & pharmacy |
| 关键词[WOS] | multidrug-resistance ; cancer-cells ; mechanisms ; berberine ; apoptosis ; extract ; growth ; genes ; rats ; p53 |
| 收录类别 | SCI |
| 原文出处 | false |
| 语种 | 英语 |
| WOS记录号 | WOS:000270401600006 |
| 公开日期 | 2010-11-30 |
| 源URL | [http://159.226.238.44/handle/321008/102205]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog Res & Anal Ctr, Dalian 116023, Peoples R China 2.Dalian Med Univ, Coll Pharm, Dalian, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Xiao-na,Xu, Li-na,Peng, Jin-yong,et al. In vivo Inhibition of S180 Tumors by the Synergistic Effect of the Chinese Medicinal Herbs Coptis chinensis and Evodia rutaecarpa[J]. planta medica,2009,75(11):1215-1220. |
| APA | Wang, Xiao-na,Xu, Li-na,Peng, Jin-yong,Liu, Ke-xin,Zhang, Li-hua,&Zhang, Yu-kui.(2009).In vivo Inhibition of S180 Tumors by the Synergistic Effect of the Chinese Medicinal Herbs Coptis chinensis and Evodia rutaecarpa.planta medica,75(11),1215-1220. |
| MLA | Wang, Xiao-na,et al."In vivo Inhibition of S180 Tumors by the Synergistic Effect of the Chinese Medicinal Herbs Coptis chinensis and Evodia rutaecarpa".planta medica 75.11(2009):1215-1220. |
入库方式： OAI收割
来源：大连化学物理研究所
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