Thermogelling hydrogels of poly(epsilon-caprolactone-co-d,l-lactide)-poly(ethylene glycol)-poly(epsilon-caprolactone-co-d,l-lactide) and poly(epsilon-caprolactone-co-l-lactide)poly(ethylene glycol)-poly(epsilon-caprolactone-co-l-lactide) aqueous solutions
文献类型：期刊论文
| 作者 | Jiang, Zhiqiang; Deng, Xianmo; Hao, Jianyuan |
| 刊名 | Journal of polymer science part a-polymer chemistry
 |
| 出版日期 | 2007-09-01 |
| 卷号 | 45期号:17页码:4091-4099 |
| 关键词 | Biomaterials Block copolymers Drug delivery systems Hydrogels Micelles Phase behavior Structure-property relations Transesterification |
| ISSN号 | 0887-624X |
| DOI | 10.1002/pola.22222 |
| 通讯作者 | Hao, jianyuan(j.hao@cioc.ac.cn) |
| 英文摘要 | Thermogelling poly(,epsilon-caprolactone-co-d,l-lactide)-poly(ethylene glycol)poly(epsilon-caprolactone-co-d,l-lactide) and poly(e-caprolactone-co-l-lactide)-poly(ethylene glycol)-poly(p.-caprolactone-co-l-lactide) triblock copolymers were synthesized through the ring-opening polymerization of e-caprolactone and d,l-lactide or l-lactide in the presence of poly(ethylene glycol). the polymerization reaction was carried out in 1,3,5-trimethylbenzene with sn(oct)(2) as the catalyst at various temperatures, and the yields were about 96%. the molecular weights and polydispersities (m-w/m-n) by gel permeation chromatography were in the ranges of 5140-6750 and 1.35-1.45, respectively. the differential scanning calorimetry results showed that the melting temperatures of the poly(g-caprolactone) components were between 30 and 40 degrees c. by the subtle tuning of the chemical compositions and microstructures of these triblock copolymers, the aqueous solutions underwent sol-gel transitions as the temperature increased, with the suitable lower critical solution temperature in the range of 1728 degrees c at different concentrations. transesterification in the polymerization process generated the redistribution of sequences, which remarkably affected the sol-gel transition temperature. the amphiphilic copolymers formed micelles in aqueous solutions with a diameter of 62 nm and a critical micelle concentration of about 0.032 wt % at 20 degrees c. micelles aggregated as the temperature increased, leading to gel formation. the sol-gel transition was studied, with a focus on the structure-property relationship. it is expected to have potential applications in drug delivery and tissue engineering. |
| WOS关键词 | BIODEGRADABLE TRIBLOCK COPOLYMER ; RING-OPENING POLYMERIZATION ; DRUG-DELIVERY SYSTEMS ; PLGA-PEG-PLGA ; EPSILON-CAPROLACTONE ; BLOCK-COPOLYMERS ; POLY(D,L-LACTIDE-RAN-EPSILON-CAPROLACTONE)-POLY(ETHYLENE GLYCOL)-POLY(D,L-LACTIDE-RAN-EPSILON-CAPROLACTONE) ; HYDROLYTIC DEGRADATION ; ANIONIC-POLYMERIZATION ; ALKALI GRAPHITIDES |
| WOS研究方向 | Polymer Science |
| WOS类目 | Polymer Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000249312900031 |
| 出版者 | JOHN WILEY & SONS INC |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2383526 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Hao, Jianyuan |
| 作者单位 | 1.Chinese Acad Sci, Chengdu Inst Organ Chem, Chengdu 610041, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jiang, Zhiqiang,Deng, Xianmo,Hao, Jianyuan. Thermogelling hydrogels of poly(epsilon-caprolactone-co-d,l-lactide)-poly(ethylene glycol)-poly(epsilon-caprolactone-co-d,l-lactide) and poly(epsilon-caprolactone-co-l-lactide)poly(ethylene glycol)-poly(epsilon-caprolactone-co-l-lactide) aqueous solutions[J]. Journal of polymer science part a-polymer chemistry,2007,45(17):4091-4099. |
| APA | Jiang, Zhiqiang,Deng, Xianmo,&Hao, Jianyuan.(2007).Thermogelling hydrogels of poly(epsilon-caprolactone-co-d,l-lactide)-poly(ethylene glycol)-poly(epsilon-caprolactone-co-d,l-lactide) and poly(epsilon-caprolactone-co-l-lactide)poly(ethylene glycol)-poly(epsilon-caprolactone-co-l-lactide) aqueous solutions.Journal of polymer science part a-polymer chemistry,45(17),4091-4099. |
| MLA | Jiang, Zhiqiang,et al."Thermogelling hydrogels of poly(epsilon-caprolactone-co-d,l-lactide)-poly(ethylene glycol)-poly(epsilon-caprolactone-co-d,l-lactide) and poly(epsilon-caprolactone-co-l-lactide)poly(ethylene glycol)-poly(epsilon-caprolactone-co-l-lactide) aqueous solutions".Journal of polymer science part a-polymer chemistry 45.17(2007):4091-4099. |
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来源：中国科学院大学
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