Predicting the distance between antibody's interface residue and antigen to recognize antigen types by support vector machine
文献类型：期刊论文
| 作者 | Shi, Yong; Zhang, Xinyang; Wan, Jia; Wang, Yong; Yin, Wei; Cao, Zhiwei; Guo, Yajun |
| 刊名 | Neural computing & applications
 |
| 出版日期 | 2007-05-01 |
| 卷号 | 16期号:4-5页码:481-490 |
| 关键词 | Bioinformatics Protein Protein data bank Antibody-antigen complexes Support vector machine Cross-validation |
| ISSN号 | 0941-0643 |
| DOI | 10.1007/s00521-006-0076-4 |
| 通讯作者 | Shi, yong(yshi@gucas.ac.cn) |
| 英文摘要 | In this paper, a machine learning approach, known as support vector machine (svm) is employed to predict the distance between antibody's interface residue and antigen in antigen-antibody complex. the heavy chains, light chains and the corresponding antigens of 37 antibodies are extracted from the antibody-antigen complexes in protein data bank. according to different distance ranges, sequence patch sizes and antigen classes, a number of, computational experiments are conducted to describe the distance between antibody's interface residue and antigen with antibody sequence information. the high prediction accuracy of both self-consistent and cross-validation tests indicates that the sequential discovered information from antibody structure characterizes much in predicting the distance between antibody's interface residue and antigen. furthermore, the antigen class is predicted from residue composition information that belongs to different distance range by svm, which shows some potential significance. |
| WOS关键词 | PROTEIN INTERACTION SITES ; SOLVENT ACCESSIBILITY ; PATTERN-RECOGNITION ; EXPRESSION DATA ; SEQUENCE ; CLASSIFICATION ; INFORMATION ; NETWORKS ; COMPLEX |
| WOS研究方向 | Computer Science |
| WOS类目 | Computer Science, Artificial Intelligence |
| 语种 | 英语 |
| WOS记录号 | WOS:000247428700015 |
| 出版者 | SPRINGER |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2383551 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Shi, Yong |
| 作者单位 | 1.Chinese Acad Sci, Grad Univ, Res Ctr Data Technol & Knowledge Econ, Beijing 100080, Peoples R China 2.Chinese Acad Sci, Inst Biophys, Beijing 100101, Peoples R China 3.Osaka Sangyo Univ, Dept Elect Engn & Elect, Osaka 5748530, Japan 4.Shanghai Ctr Bioinformat Technol, Shanghai 200235, Peoples R China 5.Shanghai Int Canc Inst China, Shanghai 200433, Peoples R China |
| 推荐引用方式 GB/T 7714 | Shi, Yong,Zhang, Xinyang,Wan, Jia,et al. Predicting the distance between antibody's interface residue and antigen to recognize antigen types by support vector machine[J]. Neural computing & applications,2007,16(4-5):481-490. |
| APA | Shi, Yong.,Zhang, Xinyang.,Wan, Jia.,Wang, Yong.,Yin, Wei.,...&Guo, Yajun.(2007).Predicting the distance between antibody's interface residue and antigen to recognize antigen types by support vector machine.Neural computing & applications,16(4-5),481-490. |
| MLA | Shi, Yong,et al."Predicting the distance between antibody's interface residue and antigen to recognize antigen types by support vector machine".Neural computing & applications 16.4-5(2007):481-490. |
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来源：中国科学院大学
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