Crystal structure study on human s100a13 at 2.0 angstrom resolution
文献类型：期刊论文
| 作者 | Li, Mei; Zhang, Ping-Feng; Pan, Xiao-Wei; Chang, Wen-Rui |
| 刊名 | Biochemical and biophysical research communications
 |
| 出版日期 | 2007-05-11 |
| 卷号 | 356期号:3页码:616-621 |
| 关键词 | S100a13 Crystal structure Calcium-binding protein Amphiphilic helix |
| ISSN号 | 0006-291X |
| DOI | 10.1016/j.bbrc.2007.03.014 |
| 通讯作者 | Li, mei(meili@moon.ibp.ac.cn) |
| 英文摘要 | The s100 protein family is the largest group of calcium-binding protein families, which consists of at least 25 members. s100a13, which is widely expressed in a variety of tissues, is a unique member of the s100 protein family. previous reports showed that s100a13 might be involved in the stress-induced release of some signal peptide-less proteins (such as fgf-1 and il-1 alpha) and also associated with inflammatory functions. it was also reported that s100a13 is a new angiogenesis marker. here we report the crystal structure of the ca2+-bound form of s100a13 at 2.0 angstrom resolution. s100a13 is a homodimer with four ef-hand motifs in an asymmetric unit, displaying a folding pattern similar to other s100 members. however, s100a13 has the unique structural feature with all alpha-helices being amphiphilic, which was not found in other members of s100s. we propose that this characteristic structure of s100a13 might be related to its ability to mediate the release of fgf-1 and il-1 alpha. (c) 2007 elsevier inc. all rights reserved. |
| WOS关键词 | PROTEIN FAMILY ; BINDING ; RELEASE ; FIBROBLAST-GROWTH-FACTOR-1 ; CRYSTALLOGRAPHY ; REFINEMENT ; IL-1-ALPHA ; COMPLEX ; STRESS ; SYSTEM |
| WOS研究方向 | Biochemistry & Molecular Biology ; Biophysics |
| WOS类目 | Biochemistry & Molecular Biology ; Biophysics |
| 语种 | 英语 |
| WOS记录号 | WOS:000245740900016 |
| 出版者 | ACADEMIC PRESS INC ELSEVIER SCIENCE |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2384113 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Li, Mei |
| 作者单位 | 1.Chinese Acad Sci, Inst Biophys, Natl Lab Biomacromol, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Mei,Zhang, Ping-Feng,Pan, Xiao-Wei,et al. Crystal structure study on human s100a13 at 2.0 angstrom resolution[J]. Biochemical and biophysical research communications,2007,356(3):616-621. |
| APA | Li, Mei,Zhang, Ping-Feng,Pan, Xiao-Wei,&Chang, Wen-Rui.(2007).Crystal structure study on human s100a13 at 2.0 angstrom resolution.Biochemical and biophysical research communications,356(3),616-621. |
| MLA | Li, Mei,et al."Crystal structure study on human s100a13 at 2.0 angstrom resolution".Biochemical and biophysical research communications 356.3(2007):616-621. |
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来源：中国科学院大学
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