Preparation of isoquinolinecarboxylic acid derivative as brush-type chiral stationary phase and its application in the enantiomeric resolutions of binaphthol derivatives
文献类型：期刊论文
| 作者 | Song Rui-Juan; Guo Ying; Fu Yu; Shi Hong-Yu; Long Yuan-De; Huang Tian-Bao |
| 刊名 | Chemical journal of chinese universities-chinese
 |
| 出版日期 | 2007-01-10 |
| 卷号 | 28期号:1页码:56-58 |
| 关键词 | Isoquinoline derivative Chiral stationary phase Binaphthol derivative Organic modifier |
| ISSN号 | 0251-0790 |
| 通讯作者 | Huang tian-bao(tbhuang@cioc.ac.cn) |
| 英文摘要 | A novel chiral stationary phase(csp) for hplc was prepared by synthesizing 3,5-dinitrobenzoyl-(s)-1 2, 3,4-tetrahydro-3- isoquinolinecarboxylic acid as chiral selector and bonding it with 3- aminopropylsilane modified silica. the resolutions of 8 enantiomers of binaphthol and its derivatives were achieved by using hexane-ethanol-acetic acid(98: 2: 0.5, volume ratio) as mobile phase with a column temperature 30 degrees c and detected at ultraviolet 254 nm. the effects of acetic acid and alcohol organic modifiers on retention and resolutions of the analytes were examined. the enantioselectivities alpha of the analytes on csp could be improved by adding acetic acid to mobile phase due to masking effect of h+ on the residing silanol and amino group. |
| WOS研究方向 | Chemistry |
| WOS类目 | Chemistry, Multidisciplinary |
| 语种 | 英语 |
| WOS记录号 | WOS:000243581800013 |
| 出版者 | HIGHER EDUCATION PRESS |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2384123 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Huang Tian-Bao |
| 作者单位 | 1.Chinese Acad Sci, Chengdu Inst Organ Chem, Chengdu 610041, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Song Rui-Juan,Guo Ying,Fu Yu,et al. Preparation of isoquinolinecarboxylic acid derivative as brush-type chiral stationary phase and its application in the enantiomeric resolutions of binaphthol derivatives[J]. Chemical journal of chinese universities-chinese,2007,28(1):56-58. |
| APA | Song Rui-Juan,Guo Ying,Fu Yu,Shi Hong-Yu,Long Yuan-De,&Huang Tian-Bao.(2007).Preparation of isoquinolinecarboxylic acid derivative as brush-type chiral stationary phase and its application in the enantiomeric resolutions of binaphthol derivatives.Chemical journal of chinese universities-chinese,28(1),56-58. |
| MLA | Song Rui-Juan,et al."Preparation of isoquinolinecarboxylic acid derivative as brush-type chiral stationary phase and its application in the enantiomeric resolutions of binaphthol derivatives".Chemical journal of chinese universities-chinese 28.1(2007):56-58. |
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来源：中国科学院大学
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