Thermomyces lanuginosus lipase-catalyzed regioselective acylation of nucleosides: Enzyme substrate recognition
文献类型：期刊论文
| 作者 | Li, Ning1,2; Zong, Min-Hua1; Ma, Ding2 |
| 刊名 | journal of biotechnology
 |
| 出版日期 | 2009-03-25 |
| 卷号 | 140期号:3-4页码:250-253 |
| 关键词 | Thermomyces lanuginosus lipase Nucleoside Substrate recognition Substrate engineering Enzymatic acylation Regioselectivity |
| 产权排序 | 2;1 |
| 通讯作者 | minhua zong ; 马丁 |
| 英文摘要 | substrate recognition of thermomyces lanuginosus lipase in the acylation of nucleosides was revealed through rational substrate engineering for the first time. t lanuginosus lipase displayed higher catalytic activities and excellent 5'-regioselectivities (94 -> 99%) in the acylation of ribonucleosides 1f-1j as compared to those in the acylation of 2'-deoxynucleosides la-le. the higher reaction rates and excellent 5'-regioselectivities might derive from a favorable hydrogen bonding between the 2'-hydroxyl group of 1f-1j and phenolic hydroxyl group of tyr21 present in the hydrophilic region of the lipase. crown copyright (c) 2009 published by elsevier b.v. all rights reserved. |
| WOS标题词 | science & technology ; life sciences & biomedicine |
| 类目[WOS] | biotechnology & applied microbiology |
| 研究领域[WOS] | biotechnology & applied microbiology |
| 关键词[WOS] | pseudomonas-cepacia lipase ; humicola-lanuginosa ; ester derivatives ; ionic liquid ; clinical-use ; 1-beta-d-arabinofuranosylcytosine ; systems ; enantioselectivity ; chemotherapy ; floxuridine |
| 收录类别 | SCI |
| 原文出处 | false |
| 语种 | 英语 |
| WOS记录号 | WOS:000265465500015 |
| 公开日期 | 2010-11-30 |
| 源URL | [http://159.226.238.44/handle/321008/102329]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.S China Univ Technol, Lab Appl Biocatalysis, Guangzhou 510640, Peoples R China 2.Chinese Acad Sci, Dalian Inst Chem Phys, State Key Lab Catalysis, Dalian 116023, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Ning,Zong, Min-Hua,Ma, Ding. Thermomyces lanuginosus lipase-catalyzed regioselective acylation of nucleosides: Enzyme substrate recognition[J]. journal of biotechnology,2009,140(3-4):250-253. |
| APA | Li, Ning,Zong, Min-Hua,&Ma, Ding.(2009).Thermomyces lanuginosus lipase-catalyzed regioselective acylation of nucleosides: Enzyme substrate recognition.journal of biotechnology,140(3-4),250-253. |
| MLA | Li, Ning,et al."Thermomyces lanuginosus lipase-catalyzed regioselective acylation of nucleosides: Enzyme substrate recognition".journal of biotechnology 140.3-4(2009):250-253. |
入库方式： OAI收割
来源：大连化学物理研究所
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