Unexpected reversal of the regioselectivity in Thermomyces lanuginosus lipase-catalyzed acylation of floxuridine
文献类型：期刊论文
| 作者 | Li, Ning1,2; Zong, Min-Hua1; Ma, Ding2 |
| 刊名 | biotechnology letters
 |
| 出版日期 | 2009-08-01 |
| 卷号 | 31期号:8页码:1241-1244 |
| 关键词 | Enzymatic acylation Floxuridine Nucleoside Reversal of regioselectivity Thermomyces lanuginosus lipase |
| 产权排序 | 2;1 |
| 通讯作者 | minhua zong ; 马丁 |
| 英文摘要 | unexpected inversion of the 3':5'-regioselectivity was observed in the enzymatic methacryloylation, crotonylation and cinnamoylation of floxuridine (1.5:1, 2.3:1 and 4.4:1, respectively), where thermomyces lanuginosus lipase preferentially catalyzed the acylation of 3'-hydroxyl rather than that of 5'-hydroxyl group. the possible reason might be the presence of a remote interaction between the unsaturated bond in the acyl group and the aromatic ring of amino acid residue trp89 in the lid of the lipase. |
| WOS标题词 | science & technology ; life sciences & biomedicine |
| 类目[WOS] | biotechnology & applied microbiology |
| 研究领域[WOS] | biotechnology & applied microbiology |
| 关键词[WOS] | nucleosides ; solvent ; analogs |
| 收录类别 | SCI |
| 原文出处 | false |
| 语种 | 英语 |
| WOS记录号 | WOS:000268002100018 |
| 公开日期 | 2010-11-30 |
| 源URL | [http://159.226.238.44/handle/321008/102335]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.S China Univ Technol, Coll Light Ind & Food Sci, Lab Appl Biocatalysis, Guangzhou 510640, Peoples R China 2.Chinese Acad Sci, Dalian Inst Chem Phys, State Key Lab Catalysis, Dalian 116023, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Ning,Zong, Min-Hua,Ma, Ding. Unexpected reversal of the regioselectivity in Thermomyces lanuginosus lipase-catalyzed acylation of floxuridine[J]. biotechnology letters,2009,31(8):1241-1244. |
| APA | Li, Ning,Zong, Min-Hua,&Ma, Ding.(2009).Unexpected reversal of the regioselectivity in Thermomyces lanuginosus lipase-catalyzed acylation of floxuridine.biotechnology letters,31(8),1241-1244. |
| MLA | Li, Ning,et al."Unexpected reversal of the regioselectivity in Thermomyces lanuginosus lipase-catalyzed acylation of floxuridine".biotechnology letters 31.8(2009):1241-1244. |
入库方式： OAI收割
来源：大连化学物理研究所
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