Investigation on a potential targeting drug delivery system consisting of folate, mitoxantrone and human serum albumin
文献类型：期刊论文
| 作者 | Zhou Qiu-Ju1,2; Bi Ya-Jing1; Xiang Jun-Feng1; Tang Ya-Lin1; Yang Qian-Fan1,2; Xu Guang-Zhi1 |
| 刊名 | Chinese journal of chemistry
 |
| 出版日期 | 2008-08-01 |
| 卷号 | 26期号:8页码:1385-1389 |
| 关键词 | Targeting drug delivery system Mitoxantrone Human serum albumin Folate Cytotoxicity assay |
| ISSN号 | 1001-604X |
| 通讯作者 | Tang ya-lin(tangyl@iccas.ac.cn) |
| 英文摘要 | A potential targeting drug delivery system consisting of folate (fa), the targeting molecule, human serum albumin (hsa), the carrier, and mitoxantrone (mto), the medicine, has been designed. data obtained by uv absorption, fluorescence, and nmr techniques indicated the formation of ternary complexes and possible application to building a targeting drug delivery system by using fa, mto and hsa. furthermore, cytotoxicity assay indicated that the toxicity of the fa-hsa-mto against pc-3 cell line was 79.95%, which was much higher than thin of free mto tested in totally the same conditions. about 30% increase of the toxicity should be owed to the targeting effect of fa. thus, the feasibility and validity of a novel targeting drug delivery system, fa-hsa-mto, was confirmed. |
| WOS关键词 | MULTIPLE-SCLEROSIS ; IN-VIVO ; CHEMISTRY ; DYE |
| WOS研究方向 | Chemistry |
| WOS类目 | Chemistry, Multidisciplinary |
| 语种 | 英语 |
| WOS记录号 | WOS:000258940100006 |
| 出版者 | WILEY-BLACKWELL |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2384171 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Tang Ya-Lin |
| 作者单位 | 1.Chinese Acad Sci, BNLMS, Ctr Mol Sci,Inst Chem, State Key Lab Struct Chem Unstable & Stable Speci, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhou Qiu-Ju,Bi Ya-Jing,Xiang Jun-Feng,et al. Investigation on a potential targeting drug delivery system consisting of folate, mitoxantrone and human serum albumin[J]. Chinese journal of chemistry,2008,26(8):1385-1389. |
| APA | Zhou Qiu-Ju,Bi Ya-Jing,Xiang Jun-Feng,Tang Ya-Lin,Yang Qian-Fan,&Xu Guang-Zhi.(2008).Investigation on a potential targeting drug delivery system consisting of folate, mitoxantrone and human serum albumin.Chinese journal of chemistry,26(8),1385-1389. |
| MLA | Zhou Qiu-Ju,et al."Investigation on a potential targeting drug delivery system consisting of folate, mitoxantrone and human serum albumin".Chinese journal of chemistry 26.8(2008):1385-1389. |
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来源：中国科学院大学
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