Studies on particle size control of gelation microspheres
文献类型：期刊论文
| 作者 | Sun Ruixue1,2; Shi Jingjing1; Guo Yanchuan1,2; Chen Lijuan1 |
| 刊名 | Acta polymerica sinica
 |
| 出版日期 | 2008-08-01 |
| 期号 | 8页码:779-784 |
| 关键词 | Gelatin microspheres (gms) Emulsification-coacervation method Preparation parameters Particle size Surface morphology |
| ISSN号 | 1000-3304 |
| 通讯作者 | Sun ruixue(chenlijuan@mail.ipc.ac.cn) |
| 英文摘要 | A series of gelatin microspheres (gms) were prepared through emulsification-coacervation method in water-in-oil (w/o) emulsions. the influence of preparation parameters on particle size, surface morphology and dispensity of gms was examined. the studied preparation parameters include concentration of gelatin solutions, concentration of the emulsifier, water/oil ratio, emulsifying time, stirring speed and so on. the surface morphology, dispersity and particle sizes of gms were determined by the scanning electron microscopy (sem) semafore 4 demo software and particle size distribution graphic charts. the experimental results indicated that increasing the concentration of gelatin solution would increase the particle size of gms. when the solution concentration increasing from 0.050 g/ml to 0.200 g/ml gradually,the particle size increased correspondingly. the relationship between the two quantities was linear. on the contrary increasing the concentration of the emulsifier would decrease the particle size of gms. furthermore, the particle size reduced quickly at initial time and slowed down latterly. with the increase of emulsifier concentration from 0 to 0.020 g/ml, the mean diameters of gms decreased from 17.32 mu m to 5. 38 mu m. however, (lie particle size dwindled slowly when emulsifier concentration was higher than 0.020 g/ml. the excellent result was obtained with the condition: 0.050 g/ml of emulsifier concentration, 0.100 g/ml of gelatin solution concentration, 1/5 of water/oil ratio, 10 min of emulsifying time and 900 r/min of the stirring speed. the gms prepared at this condition had the smallest sizes,the narrowest size distribution, the best sphericity and fluidity. the water/oil ratio has the same influence on particle size of gms as that of gelatin solution concentration. with the increase of water/oil ratio the average particle size increased linearly, and the surface of microspheres became smoother as well. it is supposed that water/oil ratio can be used to change the diameters and surface morphologies of gms. the emulsifying time had little influence on the mean diameters of gms,but it affected the dispersity of gms apparently. when the emulsifying time was shorter than 5 min, the gms had bad dispersity; after increasing the emulsifying time to 13 min,the dispersity of gms changed greatly; whereas the dispersity of gms became bad again when the emulsifying time was longer than 13 min. according to the experimental results, 13 min was considered to be the best emulsifying time. the stirring speed had the similar influence on gms ' morphologies as that of emulsifying time. slow stirring rate made large size distribution and bad sphericity of gms; excessive stirring speed resulted in aggregation among gms likewise. the smaller size distribution and better sphericity of gms were observed under the stirring rate between 500 r/min to 1500 r/min by sem. in conclusion, increasing the concentration of gelatin solution or w/o ratio would increase the particle sizes of gms, increasing the concentration of the emulsifier would decrease the sizes of gms,proper emulsifying time and stirring speed would resultin in the best sphericity of gms. |
| WOS关键词 | POLYMER MICROSPHERES ; DRUG-RELEASE |
| WOS研究方向 | Polymer Science |
| WOS类目 | Polymer Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000258728100008 |
| 出版者 | SCIENCE CHINA PRESS |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2384405 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Sun Ruixue |
| 作者单位 | 1.Chinese Acad Sci, Tech Inst Phys & Chem, Beijing 100080, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Sun Ruixue,Shi Jingjing,Guo Yanchuan,et al. Studies on particle size control of gelation microspheres[J]. Acta polymerica sinica,2008(8):779-784. |
| APA | Sun Ruixue,Shi Jingjing,Guo Yanchuan,&Chen Lijuan.(2008).Studies on particle size control of gelation microspheres.Acta polymerica sinica(8),779-784. |
| MLA | Sun Ruixue,et al."Studies on particle size control of gelation microspheres".Acta polymerica sinica .8(2008):779-784. |
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来源：中国科学院大学
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